Alpha-amyrine

De WikiPhyto

Nom de la substance

Alpha-amyrine et béta-amyrine

Famille moléculaire

Triterpénoïde, triterpène pentacyclique (alcool triterpénique)

Source végétale

Propriétés

  • Protection de la peau
  • Propriétés antifongiques et antibactériennes
  • Antalgique [2], [3]
  • Anti-inflammatoire [4], dans les colites [5], [6] et dans les pancréatites aiguës [7], [8]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Liliana Hernández Vázquez, Javier Palazon, Arturo Navarro-Ocaña. The Pentacyclic Triterpenes alpha, béta-amyrins: A Review of Sources and Biological Activities texte intégral
  2. Lima-Junior RC, Oliveira FA, Gurgel LA, Cavalcante IJ, Santos KA, Campos DA, Vale CA, Silva RM, Chaves MH, Rao VS, Santos FA. Attenuation of visceral nociception by alpha- and beta-amyrin, a triterpenoid mixture isolated from the resin of Protium heptaphyllum, in mice. Planta-Med. 2006 Jan; 72(1): 34 PMID 16450293
  3. Aragão GF, Cunha Pinheiro MC, Nogueira Bandeira P, Gomes Lemos TL, de Barros Viana GS. Analgesic and anti-inflammatory activities of the isomeric mixture of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) march. J Herb Pharmacother. 2007;7(2):31-47. PMID 18285306
  4. de Oliveira LS, Tschoeke DA, de Oliveira AS, Hill LJ, Paradas WC, Salgado LT, Thompson CC, Pereira RC, Thompson FL. New Insights on the terpenome of the red seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta). Mar Drugs. 2015 Feb 10;13(2):879-902. doi: 10.3390/md13020879. PMID 25675000
  5. Vitor CE, Figueiredo CP, Hara DB, Bento AF, Mazzuco TL, Calixto JB. Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, alpha- and beta-amyrin, in a mouse model of colitis. Br J Pharmacol. 2009 Jul;157(6):1034-44. doi: 10.1111/j.1476-5381.2009.00271.x. PMID 19508397
  6. Matos I, Bento AF, Marcon R, Claudino RF, Calixto JB. Preventive and therapeutic oral administration of the pentacyclic triterpene α,β-amyrin ameliorates dextran sulfate sodium-induced colitis in mice: the relevance of cannabinoid system. Mol Immunol. 2013 Jul;54(3-4):482-92. doi: 10.1016/j.molimm.2013.01.018. PMID 23454360
  7. Melo CM, Carvalho KM, Neves JC, Morais TC, Rao VS, Santos FA, Brito GA, Chaves MH. alpha,beta-amyrin, a natural triterpenoid ameliorates L-arginine-induced acute pancreatitis in rats. World J Gastroenterol. 2010 Sep 14;16(34):4272-80. PMID 20818810
  8. Melo CM, Morais TC, Tomé AR, Brito GA, Chaves MH, Rao VS, Santos FA. Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice. Inflamm Res. 2011 Jul;60(7):673-81. doi: 10.1007/s00011-011-0321-x. PMID 21400110
  • Carretero ME, López-Pérez JL, Abad MJ, Bermejo P, Tillet S, Israel A, Noguera-P B. Preliminary study of the anti-inflammatory activity of hexane extract and fractions from Bursera simaruba (Linneo) Sarg. (Burseraceae) leaves. J Ethnopharmacol. 2008 Feb 28;116(1):11-5. PMID 18155865