Calycosine

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Nom de la substance

Calycosine (calycoside), 3′,7-Dihydroxy-4′-méthoxy-isoflavone

Famille moléculaire

Source végétale

Propriétés

  • Effet neuroprotecteur sur les lésions d'ischémie-reperfusion cérébrale chez le rat [5], [6], [7]
  • Inhibition de l’alpha-glucosidase (potentiel effet antidiabétique) [8]
  • Activité œstrogénique, érythropoïétique et ostéogénique, associée à Angelica sinensis (radix) dans les troubles ménopausiques [9]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Long-Ze Lin, Xian-Guo He, Michael Lindenmaier, Gary Nolan, Jie Yang, Michael Cleary , Sheng-Xiang Qiu , Geoffrey A. Cordell. Liquid chromatography–electrospray ionization mass spectrometry study of the flavonoids of the roots of Astragalus mongholicus and A. membranaceus. Journal of Chromatography A, 876 (2000) 87–95texte intégral
  2. Ma X, Zhang T, Wei Y, Tu P, Chen Y, Ito Y. Preparative isolation and purification of calycosin from Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao by high-speed counter-current chromatography. J Chromatogr A. 2002 Jul 12;962(1-2):243-7. PMID 12198969
  3. Ma X, Tu P, Chen Y, Zhang T, Wei Y, Ito Y. Preparative isolation and purification of isoflavan and pterocarpan glycosides from Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao by high-speed counter-current chromatography. J Chromatogr A. 2004 Jan 16;1023(2):311-5. PMID 14753698
  4. Bratkov VM, Shkondrov AM, Zdraveva PK, Krasteva IN. Flavonoids from the Genus Astragalus: Phytochemistry and Biological Activity. Pharmacogn Rev. 2016 Jan-Jun;10(19):11-32. doi: 10.4103/0973-7847.176550. PMID 27041870
  5. Wang Y, Ren Q, Zhang X, Lu H, Chen J. Neuroprotective Mechanisms of Calycosin Against Focal Cerebral Ischemia and Reperfusion Injury in Rats. Cell Physiol Biochem. 2018;45(2):537-546. doi: 10.1159/000487031. PMID 29402799
  6. Guo C, Tong L, Xi M, Yang H, Dong H, Wen A. Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats. J Ethnopharmacol. 2012 Dec 18;144(3):768-74. doi: 10.1016/j.jep.2012.09.056. PMID 23123262
  7. Guo C, Ma Y, Ma S, Mu F, Deng J, Duan J, Xiong L, Yin Y, Wang Y, Xi M, Wen A. The Role of TRPC6 in the Neuroprotection of Calycosin Against Cerebral Ischemic Injury. Sci Rep. 2017 Jun 8;7(1):3039. doi: 10.1038/s41598-017-03404-6. PMID 28596571
  8. Zhao H, Zhang Y, Guo Y, Shi S. Identification of major α-glucosidase inhibitors in Radix Astragali and its human microsomal metabolites using ultrafiltration HPLC-DAD-MS(n.). J Pharm Biomed Anal. 2015 Feb;104:31-7. doi: 10.1016/j.jpba.2014.09.029. PMID 25474715
  9. Gong AG, Li N, Lau KM, Lee PS, Yan L, Xu ML, Lam CT, Kong AY, Lin HQ, Dong TT, Tsim KW. Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of Astragali Radix and Angelica Sinensis Radix: An evaluation by using calycosin-knock out herbal extract. J Ethnopharmacol. 2015 Jun 20;168:150-7. doi: 10.1016/j.jep.2015.03.033. PMID 25796405