Férutinine
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Nom de la substance
Férutinine
Famille moléculaire
Source végétale
- Ferula hermonis Boiss [1], Ferula spp.
Propriétés
- Propriétés phytoestrogéniques, agoniste des récepteurs alpha aux estrogènes [2], [3], améliore la différenciation ostéoblastique [4], stimule la production d'oxyde nitrique (NO), ce qui peut expliquer les propriétés anti-arthritiques et l’usage comme tranquillisant, antispasmodique et aphrodisiaque [5]
- Anti-inflammatoire [6]
Effet thérapeutique
Effets indésirables
Bibliographie
- ↑ Lhuillier A, Fabre N, Cheble E, Oueida F, Maurel S, Valentin A, Fourasté I, Moulis C. Daucane sesquiterpenes from Ferula hermonis. J Nat Prod. 2005 Mar;68(3):468-71. PMID 15787464
- ↑ Appendino G, Spagliardi P, Sterner O, Milligan S. Structure--activity relationships of the estrogenic sesquiterpene ester ferutinin. Modification of the terpenoid core. J Nat Prod. 2004 Sep;67(9):1557-64. PMID 15387659
- ↑ Ikeda K, Arao Y, Otsuka H, Nomoto S, Horiguchi H, Kato S, Kayama F. Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta. Biochem Biophys Res Commun. 2002 Feb 22;291(2):354-60. PMID 11846412
- ↑ Zavatti M, Guida M, Maraldi T, Beretti F, Bertoni L, La Sala GB, De Pol A. Estrogen receptor signaling in the ferutinin-induced osteoblastic differentiation of human amniotic fluid stem cells. Life Sci. 2016 Nov 1;164:15-22. doi: 10.1016/j.lfs.2016.09.005. PMID 27629493
- ↑ Colman-Saizarbitoria T, Boutros P, Amesty A, Bahsas A, Mathison Y, Garrido Mdel R, Israel A. Ferutinin stimulates nitric oxide synthase activity in median eminence of the rat. J Ethnopharmacol. 2006 Jul 19;106(3):327-32. PMID 16574358
- ↑ Geroushi A, Auzi AA, Elhwuegi AS, Elzawam F, Elsherif A, Nahar L, Sarker SD. Antiinflammatory sesquiterpenes from the root oil of Ferula hermonis. Phytother Res. 2011 May;25(5):774-7. doi: 10.1002/ptr.3324. PMID 21520471
- ↑ Ferretti M, Bertoni L, Cavani F, Zavatti M, Resca E, Carnevale G, Benelli A, Zanoli P, Palumbo C. Influence of ferutinin on bone metabolism in ovariectomized rats. II: role in recovering osteoporosis. J Anat. 2010 Jul;217(1):48-56. doi: 10.1111/j.1469-7580.2010.01242.x. PMID 20492429
- ↑ Palumbo C, Ferretti M, Bertoni L, Cavani F, Resca E, Casolari B, Carnevale G, Zavatti M, Montanari C, Benelli A, Zanoli P. Influence of ferutinin on bone metabolism in ovariectomized rats. I: role in preventing osteoporosis. J Bone Miner Metab. 2009;27(5):538-45. doi: 10.1007/s00774-009-0070-x. PMID 19333679
- ↑ Che CT, Wong MS, Lam CW. Natural Products from Chinese Medicines with Potential Benefits to Bone Health. Molecules. 2016 Feb 27;21(3):239. doi: 10.3390/molecules21030239. PMID 26927052