Polydatine

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Nom de la substance

Polydatine, ou picéide = resvératrol-3-β-mono-D-glucoside, resvératrol 3-O-β-D-glucopyranoside

Famille moléculaire

Source végétale

Propriétés

  • Antioxydant, anti-inflammatoire, neuroprotecteur [1], [2], protecteur vis-à-vis des conséquences de l'ischémie cérébrale dans les accidents vasculaires cérébraux [3]
  • Hypolipidémiant [4], [5]
  • Hépatoprotecteur [6]
  • Améliore la stéatose hépatique non-alcoolique [7]
  • Cardioprotecteur [8]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Li RP, Wang ZZ, Sun MX, Hou XL, Sun Y, Deng ZF, Xiao K. Polydatin protects learning and memory impairments in a rat model of vascular dementia. Phytomedicine. 2012 Jun 15;19(8-9):677-81. doi: 10.1016/j.phymed.2012.03.002. PMID 22483554.
  2. Fakhri S, Gravandi MM, Abdian S, Akkol EK, Farzaei MH, Sobarzo-Sánchez E. The Neuroprotective Role of Polydatin: Neuropharmacological Mechanisms, Molecular Targets, Therapeutic Potentials, and Clinical Perspective. Molecules. 2021 Oct 2;26(19):5985. doi: 10.3390/molecules26195985. PMID 34641529; PMCID: PMC8513080.
  3. Tang KS, Tan JS. The protective mechanisms of polydatin in cerebral ischemia. Eur J Pharmacol. 2019 Jan 5;842:133-138. doi: 10.1016/j.ejphar.2018.10.039. PMID 30385347.
  4. Xing WW, Wu JZ, Jia M, Du J, Zhang H, Qin LP. Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits. Biomed Pharmacother. 2009 Aug;63(7):457-62. doi: 10.1016/j.biopha.2008.06.035. PMID 18657948.
  5. Du J, Sun LN, Xing WW, Huang BK, Jia M, Wu JZ, Zhang H, Qin LP. Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters. Phytomedicine. 2009 Jun;16(6-7):652-8. doi: 10.1016/j.phymed.2008.10.001. PMID 19106037.
  6. Karami A, Fakhri S, Kooshki L, Khan H. Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits. Molecules. 2022 Oct 1;27(19):6474. doi: 10.3390/molecules27196474. PMID 36235012; PMCID: PMC9572446.
  7. Zhang J, Tan Y, Yao F, Zhang Q. Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c. Mol Med Rep. 2012 Oct;6(4):815-20. doi: 10.3892/mmr.2012.1015. PMID 22858825.
  8. Deng J, Liu W, Wang Y, Dong M, Zheng M, Liu J. Polydatin modulates Ca(2+) handling, excitation-contraction coupling and β-adrenergic signaling in rat ventricular myocytes. J Mol Cell Cardiol. 2012 Nov;53(5):646-56. doi: 10.1016/j.yjmcc.2012.08.009. PMID 22921781.