Phlorétine

Nom de la substance

Réduit la stéatose hépatique chez la souris obèse ^[1], améliore l'homéostasie du glucose, la sensibilité à l'insuline, diminue l'accumulation de lipides hépatiques chez la souris obèse ^[2]
Diminue la virulence de Salmonella typhimurium ^[3]
Antioxydant, inhibe la croissance de cellules de cancer de prostate ^[4]

↑ Liou, CJ., Wu, SJ., Shen, SC. et al. Phloretin ameliorates hepatic steatosis through regulation of lipogenesis and Sirt1/AMPK signaling in obese mice. Cell Biosci 10, 114 (2020). https://doi.org/10.1186/s13578-020-00477-1
↑ Alsanea, S., Gao, M. & Liu, D. Phloretin Prevents High-Fat Diet-Induced Obesity and Improves Metabolic Homeostasis. AAPS J 19, 797–805 (2017). https://doi.org/10.1208/s12248-017-0053-0
↑ Shuai-Cheng, W., Ben-Dong, F., Xiu-Ling, C. et al. Subinhibitory concentrations of phloretin repress the virulence of Salmonella typhimurium and protect against Salmonella typhimurium infection. Antonie van Leeuwenhoek 109, 1503–1512 (2016). https://doi.org/10.1007/s10482-016-0752-z
↑ Kim, U., Kim, CY., Lee, J.M. et al. Phloretin Inhibits the Human Prostate Cancer Cells Through the Generation of Reactive Oxygen Species. Pathol. Oncol. Res. 26, 977–984 (2020). https://doi.org/10.1007/s12253-019-00643-y