Amygdaline
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Nom de la substance
Amygdaline, amygdaloside
Famille moléculaire
- Glucoside cyanogénétique en C20
Source végétale
- Fruit de Eriobotrya japonica (noyau [1]), noyau d'abricot et de diverses Rosaceae)
Propriétés
- Cardioprotecteur [2]
- Inhibition de l'angiogenèse des cellules endothéliales d'anneaux aortiques chez le rat diabétique [3]
- Propriétés anticancéreuses prometteuses [4], [5] mais controversées
Effet thérapeutique
Effets indésirables
- Toxicité au cyanure avec de fortes doses d'amygdaline
- Dose léthale chez l'adulte de 0.5–3.5 mg/kg
Bibliographie
- ↑ Wu, H. & Cao, C. & Zhou, C.. (2017). Determination of amygdalin in the fruit of Eriobotrya japonica lindl by high performance liquid chromatography. Biomedical Research (India). 28. 9028-9032.
- ↑ Kung Y-L, Lu C-Y, Badrealam KF, et al. Cardioprotective potential of amygdalin against angiotensin II induced cardiac hypertrophy, oxidative stress and inflammatory responses through modulation of Nrf2 and NF-κB activation. Environmental Toxicology. 2021; 36: 926–934. https://doi.org/10.1002/tox.23094
- ↑ Mirmiranpour H, Khaghani S, Zandieh A, Khalilzadeh OO, Gerayesh-Nejad S, Morteza A, Esteghamati A. Amygdalin inhibits angiogenesis in the cultured endothelial cells of diabetic rats. Indian J Pathol Microbiol. 2012 Apr-Jun;55(2):211-4. doi: 10.4103/0377-4929.97874. PMID 22771646.
- ↑ Spanoudaki M, Stoumpou S, Papadopoulou SK, Karafyllaki D, Solovos E, Papadopoulos K, Giannakoula A, Giaginis C. Amygdalin as a Promising Anticancer Agent: Molecular Mechanisms and Future Perspectives for the Development of New Nanoformulations for Its Delivery. Int J Mol Sci. 2023 Sep 19;24(18):14270. doi: 10.3390/ijms241814270. PMID: 37762572; PMCID: PMC10531689.
- ↑ Jaszczak-Wilke E, Polkowska Ż, Koprowski M, Owsianik K, Mitchell AE, Bałczewski P. Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds. Molecules. 2021 Apr 13;26(8):2253. doi: 10.3390/molecules26082253. PMID 33924691; PMCID: PMC8069783.