Ascaridole

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Nom de la substance

Ascaridole

Famille moléculaire

Peroxyde monoterpénique asymétrique

Source végétale

Propriétés

  • Vermifuge anthelminthique, très toxique (oxydant puissant)
  • Sédatif [1]

Effet thérapeutique

Effets indésirables

  • Toxique [6], au tableau C
  • Toxicité mitochondriale [7]

Bibliographie

  1. Okuyama, E., Umeyama, K., Saito, Y., Yamazaki, M., & Satake, M. (1993). Ascaridole as a pharmacologically active principle of" Paico", a medicinal Peruvian plant. Chemical and pharmaceutical bulletin, 41(7), 1309-1311.
  2. Monzote L, Geroldinger G, Tonner M, Scull R, De Sarkar S, Bergmann S, Bacher M, Staniek K, Chatterjee M, Rosenau T, Gille L. Interaction of ascaridole, carvacrol, and caryophyllene oxide from essential oil of Chenopodium ambrosioides L. with mitochondria in Leishmania and other eukaryotes. Phytother Res. 2018 Sep;32(9):1729-1740. doi: 10.1002/ptr.6097. PMID 29672979
  3. Pastor J, García M, Steinbauer S, Setzer WN, Scull R, Gille L, Monzote L. Combinations of ascaridole, carvacrol, and caryophyllene oxide against Leishmania. Acta Trop. 2015 May;145:31-8. doi: 10.1016/j.actatropica.2015.02.002. PMID 25697866
  4. Monzote L, García M, Pastor J, Gil L, Scull R, Maes L, Cos P, Gille L. Essential oil from Chenopodium ambrosioides and main components: activity against Leishmania, their mitochondria and other microorganisms. Exp Parasitol. 2014 Jan;136:20-6. doi: 10.1016/j.exppara.2013.10.007. PMID 24184772
  5. Pollack, Y., Segal, R., & Golenser, J. (1990). The effect of ascaridole on the in vitro development of Plasmodium falciparum. Parasitology Research, 76(7), 570-572.
  6. Monzote L, Stamberg W, Staniek K, Gille L. Toxic effects of carvacrol, caryophyllene oxide, and ascaridole from essential oil of Chenopodium ambrosioides on mitochondria. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):337-47. doi: 10.1016/j.taap.2009.08.001. PMID 19666043
  7. Gille L, Monzote L, Stamberg W, Staniek K. Toxicity of ascaridole from Chenopodium ambrosioides in mammalian mitochondria. BMC Pharmacol. 2010;10(Suppl 1):A10. Published 2010 Nov 16. doi:10.1186/1471-2210-10-S1-A10