Asiaticoside

De WikiPhyto

Nom de la substance

Asiaticoside

Famille moléculaire

Saponoside triterpénique

Source végétale

Propriétés

  • Vulnéraire [1]
  • Stimulant de la biosynthèse du collagène [2]
  • Neuroprotection vis-à-vis des maladies neurodégénératives et surtout de la maladie de Parkinson [3], [4], [5], [6]
  • Protection vis-à-vis de la protéine béta-amyloïde [7], [8]

Effet thérapeutique

  • Cicatrisation des plaies
  • Insuffisance veineuse, plaies variqueuses
  • Maladie d'Alzheimer (?)

Effets indésirables

Bibliographie

  1. Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol. 1999 Apr;65(1):1-11. PMID 10350364
  2. Lee J, Jung E, Kim Y, Park J, Park J, Hong S, Kim J, Hyun C, Kim YS, Park D. Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling. Planta Med. 2006 Mar;72(4):324-8. PMID 16557473
  3. Haleagrahara N, Ponnusamy K. Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats. J Toxicol Sci. 2010 Feb;35(1):41-7. PMID 20118623
  4. Xu CL, Qu R, Zhang J, Li LF, Ma SP. Neuroprotective effects of madecassoside in early stage of Parkinson's disease induced by MPTP in rats. Fitoterapia. 2013 Oct;90:112-8. doi: 10.1016/j.fitote.2013.07.009. PMID 23876367
  5. Xu CL, Wang QZ, Sun LM, Li XM, Deng JM, Li LF, Zhang J, Xu R, Ma SP. Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax. Pharmacol Biochem Behav. 2012 Jan; 100(3):413-8. PMID 22001429
  6. Subathra M, Shila S, Devi MA, Panneerselvam C. Emerging role of Centella asiatica in improving age-related neurological antioxidant status. Exp Gerontol. 2005 Aug-Sep;40(8-9):707-15. PMID 16026958
  7. Mook-Jung I, Shin JE, Yun SH, Huh K, Koh JY, Park HK, Jew SS, Jung MW. Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity. J Neurosci Res. 1999 Nov 1;58(3):417-25. PMID 10518115
  8. Hossain S, Hashimoto M, Katakura M, Al Mamun A, Shido O. Medicinal value of asiaticoside for Alzheimer's disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico docking. BMC Complementary and Alternative Medicine 2015, 15:118 (14 April 2015) Abstract texte intégral