Béta-lapachone

De WikiPhyto

Nom de la substance

Béta-lapachone

Famille moléculaire

  • Naphtoquinone

Source végétale

Propriétés

  • Antitumoral par activité sur DNA topoisomérase I, NAD(P)H:quinone oxydoréductase [1], DT-diaphorase, Xip3 [2], inducteur d'apoptose [3], [4], [5]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Pink JJ, Planchon SM, Tagliarino C, Varnes ME, Siegel D, Boothman DA. NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J Biol Chem. 2000 Feb 25;275(8):5416-24. PMID 10681517
  2. Pardee AB, Li YZ, Li CJ. Cancer therapy with beta-lapachone. Curr Cancer Drug Targets. 2002 Sep;2(3):227-42. PMID 12188909
  3. Planchon SM, Pink JJ, Tagliarino C, Bornmann WG, Varnes ME, Boothman DA. beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3. Exp Cell Res. 2001 Jul 1;267(1):95-106. PMID 11412042
  4. Jeon YJ, Bang W, Shin JC, Park SM, Cho JJ, Choi YH, Seo KS, Choi NJ, Shim JH, Chae JI. Downregulation of Sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous cell carcinoma. Int J Oncol. 2015 Jun;46(6):2606-12. doi: 10.3892/ijo.2015.2972. PMID 25891355
  5. Yu HY, Kim SO, Jin CY, Kim GY, Kim WJ, Yoo YH, Choi YH. β-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway. Biomol Ther (Seoul). 2014 May;22(3):184-92. doi: 10.4062/biomolther.2014.026. PMID 25009698