Cinnamtanin

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Nom de la substance

Cinnamtanin

Famille moléculaire

Source végétale

Propriétés

  • Antioxydant [1]
  • Protection des cellules pancréatiques bêta (cinnamtanin D-1) [2], [3]
  • Neuroprotecteur (cinnamtanin B-1), protège les astrocytes [4]
  • Antidiabétique (cinnamtanin A2), augmente le GLP-1 et la sécrétion d'insuline chez la souris [5]
  • Anti-agrégant plaquettaire (cinnamtanin B-1) [6], [7], [8]
  • Inhibition de l'enzyme HIV-intégrase [9]
  • Induit l'apoptose dans des cellules de cancer du colon (cinnamtanin B-1) [10]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. HO, K.Y., HUANG, J.S., TSAI, C.C., LIN, T.C., HSU, Y.F. and LIN, C.C. (1999), Antioxidant Activity of Tannin Components from Vaccinium vitis‐idaea L.. Journal of Pharmacy and Pharmacology, 51: 1075-1078. https://doi.org/10.1211/0022357991773410
  2. Wang, T., Sun, P., Chen, L., Huang, Q., Chen, K., Jia, Q., ... & Wang, H. (2014). Cinnamtannin D-1 protects pancreatic β-cells from palmitic acid-induced apoptosis by attenuating oxidative stress. Journal of agricultural and food chemistry, 62(22), 5038-5045.
  3. Chen, L., Chen, L., Wang, T., Yuan, P., Chen, K., Jia, Q., ... & Li, Y. (2016). Preparation of Methylated Products of A‐type Procyanidin Trimers in Cinnamon Bark and Their Protective Effects on Pancreatic β‐Cell. Journal of food science, 81(5), C1062-C1069.
  4. Chi, Z., Ma, X., Cui, G., Li, M., & Li, F. (2013). Cinnamtannin B-1 regulates cell proliferation of spinal cord astrocytes and protects the cell from oxygen-glucose-serum deprivation/reoxygenation-induced apoptosis. International journal of molecular sciences, 14(8), 15827-15837.
  5. Yamashita, Y., Okabe, M., Natsume, M., & Ashida, H. (2013). Cinnamtannin A2, a tetrameric procyanidin, increases GLP-1 and insulin secretion in mice. Bioscience, biotechnology, and biochemistry, 77(4), 888-891.
  6. Amor, N. B., Bouaziz, A., Romera-Castillo, C., Salido, S., Linares-Palomino, P. J., Bartegi, A., ... & Rosado, J. A. (2007). Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets. Journal of medicinal chemistry, 50(16), 3937-3944.
  7. Bouaziz, A., Salido, S., Linares-Palomino, P. J., Sanchez, A., Altarejos, J., Bartegi, A., ... & Rosado, J. A. (2007). Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients. Archives of biochemistry and biophysics, 457(2), 235-242.
  8. López, J. J., Jardín, I., Salido, G. M., & Rosado, J. A. (2008). Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor. Life sciences, 82(19-20), 977-982.
  9. Chaofeng, Z., Qishi, S., Zhengtao, W., Masao, H., & Supinya, T. (2003). Inhibitory activities of tannins extracted from stem of Lindera aggregata against HIV-1 integrase. Zhongguo yao xue za zhi (Zhongguo yao xue hui: 1989), 38(12), 911-914.
  10. Carriere, P. P., Kapur, N., Mir, H., Ward, A. B., & Singh, S. (2018). Cinnamtannin B-1 inhibits cell survival molecules and induces apoptosis in colon cancer. International journal of oncology, 53(4), 1442-1454.
  • Salleh, W., & Hakimi, W. M. N. (2020). Lindera aggregata (Sims) Kosterm: Review on phytochemistry and biological activities. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 19(6).