Curcuphénol

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Nom de la substance

Curcuphénol

Famille moléculaire

Source végétale

Propriétés

  • Activité antimicrobienne vis-à-vis de Staphylococcus aureus et Cryptococcus neoformans [2]
  • Antifongique [3]
  • Antitumoral in vitro (cellules leucémiques (P-388), cellules de cancer du poumon (A-549), du colon (HCT-8), du sein (MDAMB) [4], antiprolifératif [5]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Pontes, Wendel José Teles et al. Chemical composition and acaricidal activity of the leaf and fruit essential oils of Protium heptaphyllum (Aubl.) Marchand (Burseraceae). Acta Amaz. [online]. 2007, vol.37, n.1, pp.103-109. ISSN 0044-5967. http://dx.doi.org/10.1590/S0044-59672007000100012.
  2. El Sayed KA, Yousaf M, Hamann MT, Avery MA, Kelly M, Wipf P. Microbial and chemical transformation studies of the bioactive marine sesquiterpenes (S)-(+)-curcuphenol and curcudiol isolated from a deep reef collection of the Jamaican sponge Didiscus oxeata. J Nat Prod 2002;65:1547–53.
  3. Gaspar H, Feio SS, Rodrigues AI, Van Soest R. Antifungal Activity of (+)-Curcuphenol, a Metabolite from the Marine Sponge Didiscus oxeata. Marine Drugs. 2004;2(1):8-13.
  4. Wright AE, Pomponi SA, McConnell OJ, Kohmoto S, McCarthy PJ. (+)- Curcuphenol and (+)-curcudiol, sesquiterpene phenols from shallow and deep water collections of the marine sponge Didiscus flavus. J Nat Prod 1987;50:976–8.
  5. Rodrigo G, Almanza GR, Cheng Y, Peng J, Hamann M, Duan RD, Akesson B. Antiproliferative effects of curcuphenol, a sesquiterpene phenol. Fitoterapia. 2010 Oct;81(7):762-6. doi: 10.1016/j.fitote.2010.04.001. PMID 20385210