Cyclotides

De WikiPhyto

Nom de la substance

Cyclotides

Famille moléculaire

  • Protéines végétales au squelette cyclique, riches en ponts disulfure et caractérisées par un un nœud cystine

Le nom de cyclotide provient de la contraction des deux termes cyclo- peptide

Source végétale

Propriétés

  • Activité anti-microbienne [1], [2] et insecticide [3], [4]
  • Activités anti-HIV
  • Inhibition de la neurotensine

Effet thérapeutique

  • Bactéricide sur infections cutanées à Staphylococcus aureus [5]

Effets indésirables

Bibliographie

  1. Pränting M, Lööv C, Burman R, Göransson U, Andersson DI. The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria. J Antimicrob Chemother. 2010 Sep;65(9):1964-71. doi: 10.1093/jac/dkq220. PMID 20558471
  2. Zarrabi M, Dalirfardouei R, Sepehrizade Z, Kermanshahi RK. Comparison of the antimicrobial effects of semipurified cyclotides from Iranian Viola odorata against some of plant and human pathogenic bacteria. J Appl Microbiol. 2013 Aug;115(2):367-75. doi: 10.1111/jam.12251. PMID 23800264
  3. Cameron Jennings, Jenny West, Clement Waine, David Craik, Marilyn Anderson. Biosynthesis and insecticidal properties of plant cyclotides: The cyclic knotted proteins from Oldenlandia affinis. Proc Natl Acad Sci U S A. 2001 September 11; 98(19): 10614–10619.[1]
  4. Craik DJ, Simonsen S, Daly NL. The cyclotides: novel macrocyclic peptides as scaffolds in drug design. Curr Opin Drug Discov Devel. 2002 Mar;5(2):251-60. PMID 11926131
  5. Fensterseifer IC, Silva ON, Malik U, Ravipati AS, Novaes NR, Miranda PR, Rodrigues EA, Moreno SE, Craik DJ, Franco OL. Effects of cyclotides against cutaneous infections caused by Staphylococcus aureus. Peptides. 2015 Jan;63:38-42. doi: 10.1016/j.peptides.2014.10.019. PMID 25451333
  • Gunasekera S, Daly NL, Anderson MA, Craik DJ. Chemical synthesis and biosynthesis of the cyclotide family of circular proteins. IUBMB Life. 2006 Sep;58(9):515-24. PMID 17002979
  • Jagadish K, Camarero JA. Cyclotides, a promising molecular scaffold for peptide-based therapeutics. Biopolymers. 2010;94(5):611-6. PMID 20564025, texte intégral : [2]