Damnacanthal

De WikiPhyto

Nom de la substance

Damnacanthal

Famille moléculaire

Anthraquinone

Source végétale

Propriétés

  • Inhibiteur sélectif de la tyrosine kinase p56lck [2]
  • Anti-inflammatoire [3] et antalgique [4]

Effet thérapeutique

  • Contribue aux propriétés anticancéreuses du noni

Effets indésirables

Bibliographie

  1. Anekpankul T, Goto M, Sasaki M, Pavasant P, Shotipruk A. Extraction of anti- cancer damnacanthal from roots of Morinda citrifolia by subcritical water. Separation and Purification Technology Volume 55, Issue 3, 1 July 2007, Pages 343–349. doi:10.1016/j.seppur.2007.01.004 [1]
  2. Faltynek CR, Schroeder J, Mauvais P, Miller D, Wang S, Murphy D, Lehr R, Kelley M, Maycock A, Michne W, et al. Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity. Biochemistry. 1995 Sep 26;34(38):12404-10. PMID 7547985
  3. Nualsanit T, Rojanapanthu P, Gritsanapan W, Kwankitpraniti T, Min KW, Baek SJ. Damnacanthal-induced anti-inflammation is associated with inhibition of NF-κB activity. Inflamm Allergy Drug Targets. 2011 Dec;10(6):455-63. PMID 21999179
  4. Okusada K, Nakamoto K, Nishida M, Fujita-Hamabe W, Kamiya K, Mizushina Y, Satake T, Tokuyama S. The antinociceptive and anti-inflammatory action of the CHCl3-soluble phase and its main active component, damnacanthal, isolated from the root of Morinda citrifolia. Biol Pharm Bull. 2011;34(1):103-7. PMID 21212526