Eupatoriopicrine

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Nom de la substance

Eupatoriopicrine

Famille moléculaire

Lactone sesquiterpénique

Source végétale

Propriétés

  • Activité cytostatique [1], [2], [3], [4], [5], cytotoxique vis-à-vis de cellules tumorales d’Ehrlich [6]
  • Activité antitrypanosomale (Trypanosoma brucei) [7]
  • Inhibition des enzymes phosphofructokinase, glycéraldéhyde 3-phosphate déhydrogénase, pyruvate kinase, lactate déhydrogénase [8]

Effet thérapeutique

Effets indésirables

  • Allergisante [9]

Bibliographie

  1. Woerdenbag HJ, Lemstra W, Malingré TM, Konings AW. Enhanced cytostatic activity of the sesquiterpene lactone eupatoriopicrin by glutathione depletion. Br J Cancer. 1989 Jan;59(1):68-75. PMID 2757925
  2. Woerdenbag HJ, Lemstra W, Hendriks H, Malingré TM, Konings AW. Investigation of the anti-tumor action of eupatoriopicrin against the Lewis lung tumour. Planta Med. 1987 Aug;53(4):318-22. PMID 3671551
  3. Woerdenbag HJ. Anti-Tumor Properties of Eupatoriopicrin; in vivo Test Models and Results. Planta Med. 1986 Oct;(5):430. PMID 17345396
  4. Hladoń B, Drozdz B, Grabarczyk H, Bobkiewicz T, Olszewski J. Sesquiterpene lactones. Part XIII. Cytotoxic activity of eupatolide and eupatoriopicrin on human and animal malignant cells in tissue culture in vitro. Pol J Pharmacol Pharm. 1975 Jul-Aug;27(4):429-38. PMID 1172616
  5. Hladoń B, Chodera A. Sesquiterpene lactones XVII. Cytostatic and pharmacological activity. Arch Immunol Ther Exp (Warsz). 1975;23(6):857-65. PMID 1220638
  6. Woerdenbag HJ, van der Linde JC, Kampinga HH, Malingré TM, Konings AW. Induction of DNA damage in Ehrlich ascites tumour cells by exposure to eupatoriopicrin. Biochem Pharmacol. 1989 Jul 15;38(14):2279-83. PMID 2751694
  7. Julianti T, Hata Y, Zimmermann S, Kaiser M, Hamburger M, Adams M. Antitrypanosomal sesquiterpene lactones from Saussurea costus. Fitoterapia. 2011 Oct;82(7):955-9. doi: 10.1016/j.fitote.2011.05.010. PMID 21624443
  8. Baer W, Chmiel J, Gnojkowski J, Klimek D. The effect of sesquiterpene lactones, eupatoriopicrin and hydroxyisonobilin, on the glycolytic metabolism of human lymphocytes. Int J Clin Pharmacol Ther Toxicol. 1983 Jan;21(1):41-6. PMID 6832866
  9. Rücker G, Schenkel EP, Manns D, Mayer R, Hausen BM, Heiden K. Allergenic sesquiterpene lactones from Eupatorium cannabinum L. and Kaunia rufescens (Lund ex de Candolle). Nat Toxins. 1997;5(6):223-7. PMID 9615309
  • Klimek D, Chmiel J, Baer W. The effect of sesquiterpene lactones on the synthesis of nucleic acid in cultures of human lymphocytes stimulated by phytohemagglutinin. Arch Immunol Ther Exp (Warsz). 1981;29(2):195-203. PMID 6171235