Ginkgétine

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Nom de la substance

Ginkgétine

Famille moléculaire

Source végétale

Propriétés

  • Antiviral vis-à-vis des Herpes virus type 1 (HSV-1) et 2 (HSV-2) et du Cytomegalovirus, par inhibition de la réplication et inhibition de la transcription des gènes [1]
  • Inhibiteur de la phospholipase A2, antalgique et anti-inflammatoire [2], [3], inhibe la production de prostaglandine E2 à partir de cellules RAW 264.7 induites par les lipopolysaccharides [4], inhibe la cyclooxygénase-2 et la 5-lipoxygénase [5]
  • Neuroprotecteur sur modèle de la maladie de Parkinson [6], et sur le processus d’ischémie-reperfusion expérimentale [7], [8], [9]
  • Potentialités anticancéreuses : cancer du poumon non à petites cellules [10], cancer de la prostate (inducteur d’apoptose) [11], [12], du sein [13], ostéosarcome [14], [15], côlon [16]
  • Réduit l’athérosclérose chez le rat [17]
  • Prévient l’adipogenèse [18]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. ↑ Hayashi, K. Y. O. K. O., Hayashi, T., & Morita, N. (1992). Mechanism of action of the antiherpesvirus biflavone ginkgetin. Antimicrobial agents and chemotherapy, 36(9), 1890-1893.
  2. ↑ Kim, H. K., Son, K. H., Chang, H. W., Kang, S. S., & Kim, H. P. (1999). Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from Ginkgo biloba leaves. Planta medica, 65(05), 465-467.
  3. ↑ Lim, H., Son, K. H., Chang, H. W., Kang, S. S., & Kim, H. P. (2006). Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation. Biological and Pharmaceutical Bulletin, 29(5), 1046-1049.
  4. ↑ Kwak, W. J., Han, C. K., Son, K. H., Chang, H. W., Kang, S. S., Park, B. K., & Kim, H. P. (2002). Effects of Ginkgetin from Ginkgo biloba leaves on cyclooxygenases and in vivo skin inflammation. Planta medica, 68(04), 316-321.
  5. ↑ Son, J. K., Son, M. J., Lee, E., Moon, T. C., Son, K. H., Kim, C. H., ... & Chang, H. W. (2005). Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Biological and Pharmaceutical Bulletin, 28(12), 2181-2184.
  6. ↑ Wang, Y. Q., Wang, M. Y., Fu, X. R., Peng-Yu, Gao, G. F., Fan, Y. M., ... & Shi, Z. H. (2015). Neuroprotective effects of ginkgetin against neuroinjury in Parkinson's disease model induced by MPTP via chelating iron. Free Radical Research, 49(9), 1069-1080.
  7. ↑ Tian, Z., Tang, C., & Wang, Z. (2019). Neuroprotective effect of ginkgetin in experimental cerebral ischemia/reperfusion via apoptosis inhibition and PI3K/Akt/mTOR signaling pathway activation. Journal of cellular biochemistry, 120(10), 18487-18495.
  8. ↑ Li, Q., Ye, T., Long, T., & Peng, X. (2019). Ginkgetin exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Bioscience, biotechnology, and biochemistry, 83(4), 675-683.
  9. ↑ Zhang, L., Liu, J., & Geng, T. (2019). Ginkgetin aglycone attenuates the apoptosis and inflammation response through nuclear factor‐kB signaling pathway in ischemic‐reperfusion injury. Journal of cellular biochemistry, 120(5), 8078-8085.
  10. ↑ Lou, J. S., Bi, W. C., Chan, G. K., Jin, Y., Wong, C. W., Zhou, Z. Y., ... & Tsim, K. W. (2017). Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget, 8(54), 93131.
  11. ↑ You, O. H., Kim, S. H., Kim, B., Sohn, E. J., Lee, H. J., Shim, B. S., ... & Kim, S. H. (2013). Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells. Bioorganic & medicinal chemistry letters, 23(9), 2692-2695.
  12. ↑ Jeon, Y. J., Jung, S. N., Yun, J., Lee, C. W., Choi, J., Lee, Y. J., ... & Kwon, B. M. (2015). Ginkgetin inhibits the growth of DU− 145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity. Cancer science, 106(4), 413-420.
  13. ↑ Cao, J., Tong, C., Liu, Y., Wang, J., Ni, X., & Xiong, M. M. (2017). Ginkgetin inhibits growth of breast carcinoma via regulating MAPKs pathway. Biomedicine & Pharmacotherapy, 96, 450-458.
  14. ↑ Xiong, M., Wang, L., Yu, H. L., Han, H., Mao, D., Chen, J., ... & Wang, Y. A. (2016). Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3/9. Oncology reports, 35(2), 1034-1040.
  15. ↑ Ye, Z. N., Yu, M. Y., Kong, L. M., Wang, W. H., Yang, Y. F., Liu, J. Q., ... & Li, Y. (2015). Biflavone ginkgetin, a novel Wnt inhibitor, suppresses the growth of medulloblastoma. Natural products and bioprospecting, 5(2), 91-97.
  16. ↑ Lee, Y. J., Kang, Y. R., Lee, S. Y., Jin, Y., Han, D. C., & Kwon, B. M. (2017). Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells through the modulation of b Myb and miRNA34a expression. International journal of oncology, 51(4), 1331-1342.
  17. ↑ Lian, N., Tong, J., Li, W., Wu, J., & Li, Y. (2018). Ginkgetin ameliorates experimental atherosclerosis in rats. Biomedicine & Pharmacotherapy, 102, 510-516.
  18. ↑ Cho, Y. L., Park, J. G., Kang, H. J., Kim, W., Cho, M. J., Jang, J. H., ... & Min, J. K. (2019). Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation. Pharmacological research, 139, 325-336.
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