Huperzine A
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Nom de la substance
Huperzine A
Famille moléculaire
Alcaloïde (sesquiterpène)
Source végétale
Propriétés
Effet thérapeutique
- Améliore la mémoire des sujets âgés [4]
- Potentialités dans la maladie d'Alzheimer [5], [6], [7]
- La revue Cochrane ne recommande pas pour le moment la généralisation de son usage et demande des études supplémentaires [8]
Effets indésirables
- Bradycardie
- Éviter l'association avec les autres inhibiteurs de l'acétylcholinestérase
Bibliographie
- ↑ Wang R, Tang XC. Neuroprotective effects of huperzine A, a natural cholinesterase inhibitor for the treatment of Alzheimer's disease. Neurosignals. 2005;14(1-2):71-82. PMID 15956816
- ↑ Zhang HY, Yan H, Tang XC. Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase. Cell Mol Neurobiol. 2008 Feb;28(2):173-83. PMID 17657601
- ↑ Zangara A. The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease. Pharmacol Biochem Behav. 2003 Jun;75(3):675-86. PMID 12895686
- ↑ Zhang Z, Wang X, Chen Q, Shu L, Wang J, Shan G. Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial. Zhonghua Yi Xue Za Zhi. 2002 Jul 25;82(14):941-4. PMID 12181083
- ↑ Xu SS, Gao ZX, Weng Z, Du ZM, Xu WA, Yang JS, Zhang ML, Tong ZH, Fang YS, Chai XS, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Zhongguo Yao Li Xue Bao. 1995 Sep;16(5):391-5. PMID 8701750
- ↑ Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One. 2013 Sep 23;8(9):e74916. doi: 10.1371/journal.pone.0074916. eCollection 2013. PMID 24086396
- ↑ Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm (Vienna). 2009 Apr;116(4):457-65. doi: 10.1007/s00702-009-0189-x. PMID 19221692
- ↑ Li J, Wu HM, Zhou RL, Liu GJ, Dong BR. Huperzine A for Alzheimer's disease. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD005592. doi: 10.1002/14651858.CD005592.pub2. PMID 18425924