Hypolaétine
(Redirigé depuis Hypolaétine-8-glucoside)
Nom de la substance
Hypolaétine
Famille moléculaire
- Flavonoïde : pentahydroxyflavone (lutéoline 8-hydroxylée), génie (aglycone) de divers glycosides
Source végétale
- Althaea officinalis, Hypolaena fastigiatia, Sideritis javalambrensis, Sideritis leucantha, Marchantia berteroana
Propriétés
- Antioxydant, inhibiteur de la peroxydation lipidique
- Protecteur vasculaire
- Antidiabétique par inhibition enzymatique de l’alpha-glucosidase (hypolaétine 5-O-β-D-glucuronopyranoside)
- Anti-inflammatoire (hypolaétine-8-glucoside) [1], [2], [3], [4], [5]
- Anti-ulcéreux gastrique [6], [7]
Effet thérapeutique
Effets indésirables
Bibliographie
- ↑ Alcaraz MJ, Hoult JR. Actions of flavonoids and the novel anti-inflammatory flavone, hypolaetin-8-glucoside, on prostaglandin biosynthesis and inactivation. Biochem Pharmacol. 1985 Jul 15;34(14):2477-82. doi: 10.1016/0006-2952(85)90529-5. PMID 3839399.
- ↑ Alcaraz MJ. Actions of hypolaetin-8-glucoside on the rat gut prostaglandin system. Pharmazie. 1985 Jul;40(7):504-5. PMID 3840264
- ↑ Alcaraz MJ, Hoult JR. Effects of hypolaetin-8-glucoside and related flavonoids on soybean lipoxygenase and snake venom phospholipase A2. Arch Int Pharmacodyn Ther. 1985 Nov;278(1):4-12. PMID 3938206
- ↑ Moroney MA, Alcaraz MJ, Forder RA, Carey F, Hoult JR. Selectivity of neutrophil 5-lipoxygenase and cyclo-oxygenase inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids. J Pharm Pharmacol. 1988 Nov;40(11):787-92. doi: 10.1111/j.2042-7158.1988.tb05173.x. PMID 2907559.
- ↑ M. J. Alcaraz, M. Moroney , J. R. S. Hoult. Effects of Hypolaetin-8-O-glucoside and its Aglycone in in vivo and in vitro Tests for Anti-Inflammatory agents. Planta Med 1989; 55(1): 107-108. DOI: 10.1055/s-2006-961879
- ↑ Alcaraz, M.J. and Tordera, M. (1988), Studies on the gastric anti-ulcer activity of hypolaetin-8-glucoside. Phytother. Res., 2: 85-88. https://doi.org/10.1002/ptr.2650020208
- ↑ Villar A, Gasco MA, Alcaraz MJ. Anti-inflammatory and anti-ulcer properties of hypolaetin-8-glucoside, a novel plant flavonoid. J Pharm Pharmacol. 1984 Dec;36(12):820-3. doi: 10.1111/j.2042-7158.1984.tb04884.x. PMID 6151974.