Myricitroside

Nom de la substance

Myricitroside, myricitrine, myricétine-3-O-rhamnose, myricétine-3-O-α-L-rhamnopyranoside (dérivé de la myricétine)

Famille moléculaire

Flavonoïde

Source végétale

• Épilobe (Onagraceae), certaines Juglandaceae (Juglans mandshurica) et Lauraceae (Litsea japonica), Myrica cerifera, Polygonum aviculare

Propriétés

• Antalgique , , anti-nociceptive, diminue les douleurs neuropathiques , même en présence de glutamate, substance P, capsaïcine, interleukine 1 béta (IL-1béta) et tumor necrosis factor-alpha (TNF-alpha)
• Activité antipsychotique
• Anti-inflammatoire
• Inhibiteur des MPP-2 (matrix métalloprotéinases 2) , facteur clé dans l'apparition de métastases de cancer du colon
• Inhibe la thyroperoxydase

Bibliographie

• Ko, C.H., Shen, S.C., Hsu, C.S., Chen, Y.C. Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade. Biochem. Pharmacol. (2005) [1]
• Shimizu, R., Shimabayashi, H., Moriwaki, M. Enzymatic Production of Highly Soluble Myricitrin Glycosides Using beta-Galactosidase. Biosci. Biotechnol. Biochem. (2006)
• Lee, S.Y., Min, B.S., Kim, J.H., Lee, J., Kim, T.J., Kim, C.S., Kim, Y.H., Lee, H.K. Flavonoids from the leaves of Litsea japonica and their anti-complement activity. Phytotherapy research : PTR. (2005) [2]
• Yokomizo, A., Moriwaki, M. Transepithelial permeability of myricitrin and its degradation by simulated digestion in human intestinal Caco-2 cell monolayer. Biosci. Biotechnol. Biochem. (2005)
• Complément de bibliographie sur [3]

Meotti FC, Fachinetto R, Maffi LC, Missau FC, Pizzolatti MG, Rocha JB, Santos AR. Antinociceptive action of myricitrin: involvement of the K+ and Ca2+ channels. Eur J Pharmacol. 2007 Jul 19;567(3):198-205. PMID 17467689

Meotti, F.C., Luiz, A.P., Pizzolatti, M.G., Kassuya, C.A., Calixto, J.B., Santos, A.R. Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways. J. Pharmacol. Exp. Ther. (2006) [4]

Meotti, F.C., Missau, F.C., Ferreira, J., Pizzolatti, M.G., Mizuzaki, C., Nogueira, C.W., Santos, A.R. Anti-allodynic property of flavonoid myricitrin in models of persistent inflammatory and neuropathic pain in mice. Biochem. Pharmacol. (2006) [5]

Pereira, M; Siba, IP; Chioca, LR; Correia, D; Vital, MA; Pizzolatti, MG; Santos, AR; Andreatini, R (August 2011). "Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 35(7): 1636–44. doi:10.1016/j.pnpbp.2011.06.002. PMID 21689712.

Ko, C.H., Shen, S.C., Lee, T.J., Chen, Y.C. Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells. Mol. Cancer Ther. (2005). PMID 15713899

Ferreira, A.C., Neto, J.C., da Silva, A.C., Kuster, R.M., Carvalho, D.P. Inhibition of thyroid peroxidase by Myrcia uniflora flavonoids. Chem. Res. Toxicol. (2006). PMID 16544938