Orientine

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Nom de la substance

Orientine, 5,7,3’,4’-tétrahydroxyflavone

Famille moléculaire

Source végétale

Propriétés

  • Protecteur vasculaire, inhibe l'hyperperméabilité, l'expression des molécules d'adhésion et la migration des leucocytes [1], [2]
  • Vasodilatateur [3]
  • Anxiolytique [4]
  • Radioprotecteur, protection vis-à-vis des radicaux libres [5], [6]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Ku, S. K., Kwak, S., & Bae, J. S. (2014). Orientin inhibits high glucose-induced vascular inflammation in vitro and in vivo. Inflammation, 37(6), 2164-2173.
  2. Wonhwa Lee, Sae-Kwang Ku, Jong-Sup Bae. Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo. Vascular Pharmacology, Volume 62, Issue 1, 2014, Pages 3-14, https://doi.org/10.1016/j.vph.2014.04.006.
  3. Fu, X. C., Wang, M. W., Li, S. P., Zhang, Y., & Wang, H. L. (2005). Vasodilatation produced by orientin and its mechanism study. Biological and Pharmaceutical Bulletin, 28(1), 37-41.
  4. Paladini, A. C., Marder, M., Viola, H., Wolfman, C., Wasowski, C., & Medina, J. H. (1999). Flavonoids and the central nervous system: from forgotten factors to potent anxiolytic compounds. Journal of Pharmacy and Pharmacology, 51(5), 519-526.
  5. Uma Devi P, Ganasoundari A, Vrinda B, Srinivasan KK, Unnikrishnan MK. Radiation protection by the ocimum flavonoids orientin and vicenin: mechanisms of action. Radiat Res. 2000 Oct;154(4):455-60. PMID 11023610
  6. Nayak V, Devi PU. Protection of mouse bone marrow against radiation-induced chromosome damage and stem cell death by the ocimum flavonoids orientin and vicenin. Radiat Res. 2005 Feb;163(2):165-71. PMID 15658892