Sésamine

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Nom de la substance

Sésamine

Famille moléculaire

Lignane

Source végétale

Propriétés

  • Anti-inflammatoire
  • Anti-allergique
  • Anti-hypertenseur [1], [2], [3], [4]
  • Neuro-protecteur
  • Hépato-protecteur [5]
  • Hypocholestérolémiant [6], effet potentialisé par l'alpha-tocophérol [7]
  • Inducteur d'apoptose dans le cancer de l'estomac [8], préventif du cancer du sein [9], inhibiteur de la delta-5-désaturase dans la synthèse des acides gras poly-insaturés [10]
  • Stimule la synthèse des protéoglycanes par les chondrocytes, réduit l'inflammation [11]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Matsumura Y, Kita S, Morimoto S, Akimoto K, Furuya M, Oka N, Tanaka T. Antihypertensive effect of sesamin. I. Protection against deoxycorticosterone acetate-salt-induced hypertension and cardiovascular hypertrophy. Biol Pharm Bull. 1995 Jul;18(7):1016-9. PMID 7581242
  2. Kita S, Matsumura Y, Morimoto S, Akimoto K, Furuya M, Oka N, Tanaka T. Antihypertensive effect of sesamin. II. Protection against two-kidney, one-clip renal hypertension and cardiovascular hypertrophy. Biol Pharm Bull. 1995 Sep;18(9):1283-5. PMID 8845824
  3. Matsumura Y, Kita S, Tanida Y, Taguchi Y, Morimoto S, Akimoto K, Tanaka T. Antihypertensive effect of sesamin. III. Protection against development and maintenance of hypertension in stroke-prone spontaneously hypertensive rats. Biol Pharm Bull. 1998 May;21(5):469-73. PMID 9635502
  4. Nakano D, Itoh C, Takaoka M, Kiso Y, Tanaka T, Matsumura Y. Antihypertensive effect of sesamin. IV. Inhibition of vascular superoxide production by sesamin. Biol Pharm Bull. 2002 Sep;25(9):1247-9. PMID 12230131
  5. Akimoto K, Kitagawa Y, Akamatsu T, Hirose N, Sugano M, Shimizu S, Yamada H. Protective Effects of Sesamin against Liver Damage Caused by Alcohol or Carbon Tetrachloride in Rodents. Annals of Nutrition and Metabolism 1993, Vol. 37, No. 4, pp 218–224 [1]
  6. Hirose N, Inoue T, Nishihara K, Sugano M, Akimoto K, Shimizu S, Yamada H. Inhibition of cholesterol absorption and synthesis in rats by sesamin. J Lipid Res. 1991 Apr;32(4):629-38. PMID 1856608
  7. Nakabayashi A, Kitagawa Y, Suwa Y, Akimoto K, Asami S, Shimizu S, Hirose N, Sugano M, Yamada H. alpha-Tocopherol enhances the hypocholesterolemic action of sesamin in rats. Int J Vitam Nutr Res. 1995;65(3):162-8. PMID 8829994
  8. Hibasami Hiroshige, Fujikawa Takahiko, Takeda Hidekatsu, Nishibe Sansei, Satoh Takashi, Fujisawa Toshiro, Nakashima Kunio. Induction of apoptosis by Acanthopanax senticosus HARMS and its component, sesamin in human stomach cancer KATO III cells. Oncology reports, 2000, vol. 7, no6, pp. 1213-1216
  9. Hirose N, Doi F, Ueki T, Akazawa K, Chijiiwa K, Sugano M, Akimoto K, Shimizu S, Yamada H. Suppressive effect of sesamin against 7,12-dimethylbenz[a]-anthracene induced rat mammary carcinogenesis. Anticancer Res. 1992 Jul-Aug;12(4):1259-65. PMID 1386971
  10. Sakayu Shimizu, Kengo Akimoto, Yoshifumi Shinmen, Hiroshi Kawashima, Michihiro SuganoetHideaki Yamada. Sesamin is a potent and specific inhibitor of Δ5 desaturase in polyunsaturated fatty acid biosynthesis. Lipids, Volume 26, Number 7 (1991), 512-516
  11. Warunee Srisuthtayanont, Dumnoensun Pruksakorn, Prachya Kongtawelert and Peraphan Pothacharoen. Effects of sesamin on chondroitin sulfate proteoglycan synthesis induced by interleukin-1beta in human chondrocytes. BMC Complementary and Alternative Medicine 2017, 17:286 | Published on: 31 May 2017texte intégral
  • Kong X, Ma M, Zhang Y, Weng M, Gong W, Guo L, Zhang J, Wang G, Su Q, Quan Z, Yang J. Differentiation therapy: sesamin as an effective agent in targeting cancer stem-like side population cells of human gallbladder carcinoma. BMC Complementary and Alternative Medicine 2014, 14:254 (19 July 2014) Abstract texte intégral