Shikonine

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Nom de la substance

Shikonine

Famille moléculaire

Source végétale

Propriétés

  • Utilisé comme colorant
  • Anti-inflammatoire
  • Inhibiteur de la glycolyse
  • Inhibiteur de l'adipogenèse [1]
  • Antitumoral [2], [3], toxique pour les cellules cancéreuses [1]
  • Immunostimulant [4]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Gwon SY, Ahn JY, Jung CH, Moon BK, Ha TY. Shikonin suppresses ERK 1/2 phosphorylation during the early stages of adipocyte differentiation in 3T3-L1 cells. BMC Complementary and Alternative Medicine 2013, 13:207 (6 August 2013) Abstract Provisional PDF
  2. Wei PL, Tu CC, Chen CH, Ho YS, Wu CT, Su HY, Chen WY, Liu JJ, Chang YJ. Shikonin suppresses the migratory ability of hepatocellular carcinoma cells. J Agric Food Chem. 2013 Jul 31. PMID 23899086
  3. Gong K, Li W. Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma. Free Radic Biol Med. 2011 Dec 15;51(12):2259-71. PMID 22011623
  4. Pietrosiuk A, Skopińska-Rózewska E, Furmanowa M, Wiedenfeld H, Sommer E, Sokolnicka I, Rogala E, Radomska-Leśniewska D, Bany J, Malinowski M. Immunomodulatory effect of shikonin derivatives isolated from Lithospermum canescens on cellular and humoral immunity in Balb/c mice. Pharmazie. 2004 Aug;59(8):640-2. PMID 15378856