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Nom de la substance

Terpinène-4-ol, terpinèn-4-ol (terpinéol-4), terpinène-1-ol-4, 4-terpinéol

Famille moléculaire

Alcool monoterpénique (monoterpénol)

Source végétale


  • Anti-inflammatoire [1], [2]
  • Anti-bactérien puissant (Staphylococcus sp, Streptococcus sp, Haemophilus sp, Pseudomonas sp) et antiviral, antifongique (Candida sp, levures) [3]
    • Effet anti-infectieux par activation des globules blancs, activation de la différentiation des monocytes [4]
  • Antiviral [5]
  • Anticandidosique (candidose buccale) [6] et vaginale [7], avec effet anti-inflammatoire [8], actif contre des souches de Candida résistantes au fluconazole [9]
  • Anti-parasitaire [10]
  • Anti-acnéique sur Propionibacterium acnes [11]
  • Diminue la croissance de cellules mélaniques humaines (M14) et induit l'apoptose [12]
  • Propriétés antitumorales in vitro vis-à-vis de tumeurs murines agressives, mésothéliome AE17 et mélanome B16 [13]
  • Anticonvulsivant [14], [15]
  • Diurétique, hypotenseur par relaxation musculaire vasculaire [16]

Effet thérapeutique

Effets indésirables


  1. Nogueira MN, Aquino SG, Rossa Junior C, Spolidorio DM. Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1β, IL-6 and IL-10 on human macrophages. Inflamm Res. 2014 Sep;63(9):769-78. doi: 10.1007/s00011-014-0749-x. PMID 24947163
  2. P.H. Hart, C. Brand, C.F. Carson, T.V. Riley, R.H. Prager, J.J. Finlay-Jon. Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. Inflammation Research. Volume 49, Number 11, 619-626 texte intégral
  3. Jirovetz L - Buchbauer G - Denkova Z - Stoyanova A - Murgov I - Schmidt E - Geissler M. Antimicrobial testings and gas chromatographic analysis of pure oxygenated monoterpenes 1,8- cineole, alpha-terpineol, terpinen-4-ol and camphor as well as target compounds in essential oils of pine (Pinus pinaster), rosemary (Rosmarinus officinalis), tea tree (Melaleuca alternifolia). Scientia Pharmaceutica, 2005, 73 pp. 27-38
  4. Budhiraja SS, Cullum ME, Sioutis SS, Evangelista L, Habanova ST. Biological activity of Melaleuca alternifola (Tea Tree) oil component, terpinen-4-ol, in human myelocytic cell line HL-60. J Manipulative Physiol Ther. 1999 Sep;22(7):447-53. PMID 10519561
  5. Garozzo, A., Timpanaro, R., Bisignano, B., Furneri, P. M., Bisignano, G., & Castro, A. (2009). In vitro antiviral activity of Melaleuca alternifolia essential oil. Letters in applied microbiology, 49(6), 806-808.
  6. Ninomiya K, Maruyama N, Inoue S, Ishibashi H, Takizawa T, Oshima H, Abe S. The essential oil of Melaleuca alternifolia (tea tree oil) and its main component, terpinen-4-ol protect mice from experimental oral candidiasis. Biol Pharm Bull. 2012;35(6):861-5. PMID 22687476
  7. Williams LR. Clonal production of tea tree oil high in terpinen-4-ol for use in formulations for the treatment of thrush. Complement Ther Nurs Midwifery. 1998 Oct;4(5):133-6. PMID 9830943
  8. Ninomiya K, Hayama K, Ishijima SA, Maruyama N, Irie H, Kurihara J, Abe S. Suppression of inflammatory reactions by terpinen-4-ol, a main constituent of tea tree oil, in a murine model of oral candidiasis and its suppressive activity to cytokine production of macrophages in vitro. Biol Pharm Bull. 2013;36(5):838-44. PMID 23649340
  9. Marcos-Arias C, Eraso E, Madariaga L, Quindos G. In vitro activities of natural products against oral Candida isolates from denture wearers. BMC Complementary and Alternative Medicine 2011, 11:119 (26 November 2011. Texte intégral : [1]
  10. Mikus J, Harkenthal M, Steverding D, Reichling J. In vitro Effect of Essential Oils and Isolated Mono- and Sesquiterpenes on Leishmania major and Trypanosoma brucei. Planta Med, 2000, 66 (04), pp 366-368.
  11. A. Raman, U. Weir, S.F. Bloomfield. Antimicrobial effects of tea-tree oil and its major components on Staphylococcus aureus, Staph. epidermidis and Propionibacterium acnes. Letters in Applied Microbiology, Volume 21, Issue 4, pages 242–245, October 1995
  12. Calcabrini A, Stringaro A, Toccacieli L, Meschini S, Marra M, Colone M, Salvatore G, Mondello F, Arancia G, Molinari A. Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells. J Invest Dermatol. 2004 Feb;122(2):349-60. PMID 15009716
  13. Greay SJ, Ireland DJ, Kissick HT, Levy A, Beilharz MW, Riley TV, Carson CF. Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and terpinen-4-ol. Cancer Chemother Pharmacol. 2010 Apr;65(5):877-88. doi: 10.1007/s00280-009-1093-7. PMID 19680653
  14. de Sousa DP, Nóbrega FF, de Morais LC, de Almeida RN. Evaluation of the anticonvulsant activity of terpinen-4-ol. Z Naturforsch C. 2009 Jan-Feb;64(1-2):1-5. PMID 19323258
  15. Nóbrega FF, Salvadori MG, Masson CJ, Mello CF, Nascimento TS, Leal-Cardoso JH, de Sousa DP, Almeida RN. Monoterpenoid terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies. Oxid Med Cell Longev. 2014;2014:703848. doi: 10.1155/2014/703848. PMID 25180069
  16. Lahlou S, Interaminense LF, Leal-Cardoso JH, Duarte GP. Antihypertensive effects of the essential oil of Alpinia zerumbet and its main constituent, terpinen-4-ol, in DOCA-salt hypertensive conscious rats. Fundam Clin Pharmacol. 2003 Jun;17(3):323-30. PMID 12803571