De Wikiphyto
Aller à la navigation Aller à la recherche

Nom de la substance

Plumbagine, 5-hydroxy-3-méthyl-1,4-naphthoquinone

Famille moléculaire

Source végétale


  • Potentielle activité anticancer [1], [2], [3], par interaction avec le NF-kappaB et Bcl-2 (cancer du sein) [4], FOXM1 (gliomes) [5], [6]
  • Activité antifongique [7] et antibactérienne en inhibant les pompes à efflux [8], mais cytotoxique vis-à-vis des kératinocytes, utiliser avec précautions [9]
  • Antimalarique vis-à-vis de Plasmodium falciparum [10]
  • Anti-inflammatoire [11], anti-oxydant
  • Anticoagulant (PubChem [2])

Effet thérapeutique

Effets indésirables


  1. Elsie Oommen, B. Dinesh Shenoy, N. Udupa, Ravindra Kamath, P. Uma Devi. Antitumour Efficacy of Cyclodextrin-complexed and Niosome-encapsulated Plumbagin in Mice Bearing Melanoma B16F1. Pharmacy and Pharmacology Communications, Volume 5, Issue 4, pages 281–285, April 1999 [1]
  2. Jamal MS, Parveen S, Beg MA, Suhail M, Chaudhary AG, Damanhouri GA, Abuzenadah AM, Rehan M. Anticancer compound plumbagin and its molecular targets: a structural insight into the inhibitory mechanisms using computational approaches. PLoS One. 2014 Feb 27;9(2):e87309. doi: 10.1371/journal.pone.0087309. eCollection 2014. PMID 24586269
  3. Yan W, Wang TY, Fan QM, Du L, Xu JK, Zhai ZJ, Li HW, Tang TT. Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice. Acta Pharmacol Sin. 2014 Jan;35(1):124-34. doi: 10.1038/aps.2013.152. Erratum in: Acta Pharmacol Sin. 2014 Mar;35(3):432. PMID 24384612
  4. Ahmad A, Banerjee S, Wang Z, Kong D, Sarkar FH. Plumbagin-induced apoptosis of human breast cancer cells is mediated by inactivation of NF-kappaB and Bcl-2. J Cell Biochem. 2008 Dec 15; 105(6):1461-71
  5. Niu M, Cai W, Liu H, Chong Y, Hu W, Gao S, Shi Q, Zhou X, Liu X, Yu R. Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression. J Pharmacol Sci. 2015 Jun 25. pii: S1347-8613(15)00111-5. doi: 10.1016/j.jphs.2015.06.005. PMID 26154848
  6. Liu X, Cai W, Niu M, Chong Y, Liu H, Hu W, Wang D, Gao S, Shi Q, Hu J, Zhou X, Yu R. Plumbagin induces growth inhibition of human glioma cells by downregulating the expression and activity of FOXM1. J Neurooncol. 2015 Feb;121(3):469-77. doi: 10.1007/s11060-014-1664-2. PMID 25528634
  7. Krishnaswamy M, Purushothaman KK. Plumbagin: A study of its anticancer, antibacterial & antifungal properties. Indian J Exp Biol. 1980 Aug;18(8):876-7. PMID 7461745
  8. Padhye S, Dandawate P, Yusufi M, Ahmad A, Sarkar FH. Perspectives on medicinal properties of plumbagin and its analogs. Med Res Rev. 2010 Nov 9. PMID 21064184
  9. Inbaraj JJ, Chignell CF. Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes. Chem Res Toxicol. 2004 Jan;17(1):55-62. PMID 14727919
  10. Sumsakul W, Plengsuriyakarn T, Chaijaroenkul W, Viyanant V, Karbwang J, Na-Bangchang K. Antimalarial activity of plumbagin in vitro and in animal models. BMC Complementary and Alternative Medicine 2014, 14:15 (12 January 2014) Abstract texte intégral
  11. Babula P, Adam V, Havel L, Kizek R. [Naphthoquinones and their pharmacological properties]. Ceska Slov Farm. 2007 Jun;56(3):114-20. PMID 17867522