Acide gallique

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Nom de la substance

Acide gallique, acide 3,4,5-trihydroxybenzoïque

Famille moléculaire

Source végétale


  • Anti-oxydant [1]
  • Anti-cancéreux, cytotoxique [2]inducteur de l'apoptose [3], [4] surtout dans les cancers de prostate ,[5] potentialisation par le cuivre [6]

Effet thérapeutique

Effets indésirables

  • L'acide gallique est totalement atoxique, son NOAEL est de 5000 mg / kg de poids corporel (dose la plus élevée testée) [7]


  1. Yusuf Yilmaz and Romeo T. Toledo. Major Flavonoids in Grape Seeds and Skins: Antioxidant Capacity of Catechin, Epicatechin, and Gallic Acid. Journal of Agricultural and Food Chemistry 2004 52 (2), pp 255–260
  2. Ohno Takamasa, Inoue Makoto, Ogihara Yukio. Cytotoxic activity of gallic acid against liver metastasis of mastocytoma cells P-815. Anticancer research, 2001, vol. 21, no6A, pp. 3875-3880 [1]
  3. Yoshioka Kazumi, Kataoka Tomoko, Hayashi Tomoko, Hasegawa Masami, Ishi Yaeko, Hibasami Hiroshige. Induction of apoptosis by gallic acid in human stomach cancer KATO III and colon adenocarcinoma COLO 205 cell lines. Oncology reports, 2000, vol. 7, no6, pp. 1221-1223. [2]
  4. Inoue M., Suzuki R., Koide T., Sakaguchi N., Ogihara Y. and Yabu Y. Antioxidant, Gallic Acid, Induces Apoptosis in HL-60RG Cells. Biochemical and Biophysical Research Communications, Volume 204, Issue 2, 31 October 1994, Pages 898-904
  5. Agarwal C, Tyagi A, Agarwal R. Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells. Mol Cancer Ther. 2006 Dec;5(12):3294-302. PMID 17172433
  6. Satoh K, Kadofuku T, Sakagami H. Copper, but not iron, enhances apoptosis-inducing activity of antioxidants. Anticancer research, 1997, vol. 17, no4A, pp. 2487-2490
  7. Rajalakshmi K, Devaraj H, Niranjali Devaraj S. Assessment of the no-observed-adverse-effect level (NOAEL) of gallic acid in mice. Food Chem Toxicol. 2001 Sep;39(9):919-22. PMID 11498268