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Nom de la substance

Agaritine, beta-N-(gamma-L(+)-glutamyl)-4-hydroxymethylphenylhydrazine

Famille moléculaire

  • Dérivé de la phénylhydrazine (d'arylhydrazine) [1]

Source végétale


  • Antitumoral par induction d'apoptose [2], [3] et immunostimulant [4], [5]
  • Antiviral, inhibiteur de protéases du HIV [6]

Effet thérapeutique

Effets indésirables


  1. BRUCE LEVENBERG. Isolation and Structure of Agaritine, a y-Glutamyl-substituted Arylhydrazine Derivative from Agaricaceae. THE JOURNAL. OP BIOLOGICAL CHEMISTRY Vol. 239, No. 7, July 1964
  2. Akiyama H, Endo M, Matsui T, Katsuda I, Emi N, Kawamoto Y, Koike T, Beppu H. Agaritine from Agaricus blazei Murrill induces apoptosis in the leukemic cell line U937. Biochim Biophys Acta. 2011 May;1810(5):519-25. doi: 10.1016/j.bbagen.2011.02.010. PMID 21382445
  3. Endo M, Beppu H, Akiyama H, Wakamatsu K, Ito S, Kawamoto Y, Shimpo K, Sumiya T, Koike T, Matsui T. Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells. Biochim Biophys Acta. 2010 Jul;1800(7):669-73. doi: 10.1016/j.bbagen.2010.03.016. PMID 20347942
  4. Lima CU, Cordova CO, Nóbrega Ode T, Funghetto SS, Karnikowski MG. Does the Agaricus blazei Murill mushroom have properties that affect the immune system? An integrative review. J Med Food. 2011 Jan-Feb;14(1-2):2-8. doi: 10.1089/jmf.2010.0017. PMID 21128829
  5. Chan Y, Chang T, Chan CH, Yeh YC, Chen CW, Shieh B, Li C. Immunomodulatory effects of Agaricus blazei Murill in Balb/cByJ mice. J Microbiol Immunol Infect. 2007 Jun;40(3):201-8. PMID 17639159
  6. Gao WN, Wei DQ, Li Y, Gao H, Xu WR, Li AX, Chou KC. Agaritine and its derivatives are potential inhibitors against HIV proteases. Med Chem. 2007 May;3(3):221-6. PMID 17504192