Depsidone

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Nom de la substance

Depsidone, depsidones

Famille moléculaire

Source végétale

Propriétés

  • Bien que connus depuis longtemps, ils intéressent la recherche assez récemment, avec mise en évidence de propriétés antimicrobiennes, antipaludéennes, cytotoxiques, anti-inflammatoires, anti-Hélicobacter pylori, antimycobactériennes, antihypertensives, antidiarrhéiques, antidiabétiques, phytotoxiques, anti-VIH, anti-ostéoclastogène, et inhibitrices enzymatiques : anti-tyrosinase, anti-hyaluronidase, anti-butyrylcholinestérase, anti-acétylcholinestérase [1]
  • Antioxydants, anti-inflammatoires [2]
  • Anticancéreux, cytostatiques [3], [4]
  • Antimicrobiens :
    • Antibactériens (Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Streptococcus faecalis, Proteus vulgaris, Listeria monocytogenes, Aeromonas hydrophila) [5]
    • Antifongiques (Candida albicans, Candida glabrata) [6]
    • Antiviraux [7], activité inhibitrice de l'intégrase du VIH-1 [8]
  • Activité neuroprotectrice, neurotrophique, neurogène, inhibition de l'acétylcholinestérase [9] (atranorine, acide perlatolique, acide physodique, acide usnique)

Effet thérapeutique

Effets indésirables

Bibliographie

  1. ↑ Khayat MT, Ghazawi KF, Samman WA, Alhaddad AA, Mohamed GA, Ibrahim SR. Recent advances on natural depsidones: sources, biosynthesis, structure-activity relationship, and bioactivities. PeerJ. 2023 May 12;11:e15394. doi: 10.7717/peerj.15394. PMID 37197584; PMCID: PMC10184659.
  2. ↑ Stojanović, Gordana & Stojanovic, Igor & Smelcerovic, Andrija. (2012). Lichen Depsidones as Potential Novel Pharmacologically Active Compounds. Mini-Reviews in Organic Chemistry. 9. 178-184. 10.2174/157019312800604689.
  3. ↑ Tripathi AH, Negi N, Gahtori R, Kumari A, Joshi P, Tewari LM, Joshi Y, Bajpai R, Upreti DK, Upadhyay SK. A Review of Anti-Cancer and Related Properties of Lichen-Extracts and Metabolites. Anticancer Agents Med Chem. 2022;22(1):115-142. doi: 10.2174/1871520621666210322094647. PMID 34225637.
  4. ↑ Ureña-Vacas I, González-Burgos E, Divakar PK, Gómez-Serranillos MP. Lichen Depsidones with Biological Interest. Planta Med. 2022 Sep;88(11):855-880. doi: 10.1055/a-1482-6381. PMID 34034351.
  5. ↑ Yilmaz M, Türk AO, Tay T, Kivanç M. The antimicrobial activity of extracts of the lichen Cladonia foliacea and its (-)-usnic acid, atranorin, and fumarprotocetraric acid constituents. Z Naturforsch C J Biosci. 2004 Mar-Apr;59(3-4):249-54. doi: 10.1515/znc-2004-3-423. PMID 15241936.
  6. ↑ Ibrahim, S. R., Mohamed, G. A., Al Haidari, R. A., El-Kholy, A. A., Zayed, M. F., & Khayat, M. T. (2018). Biologically active fungal depsidones: Chemistry, biosynthesis, structural characterization, and bioactivities. Fitoterapia, 129, 317-365.
  7. ↑ Odimegwu, Damian & Ejikeugwu, Chika & Esimone, C.O.. (2015). Lichen Secondary Metabolites as Possible Antiviral Agents. 165-177. 10.1007/978-3-319-13374-4_7.
  8. ↑ Nouri Neamati, Huixiao Hong, Abhijit Mazumder, Shaomeng Wang, Sanjay Sunder, Marc C. Nicklaus, George W. A. Milne, Bohumil Proksa, Yves Pommier. Depsides and Depsidones as Inhibitors of HIV-1 Integrase:  Discovery of Novel Inhibitors through 3D Database Searching. J. Med. Chem. 1997, 40, 6, 942–951, March 14, 1997 https://doi.org/10.1021/jm960759e
  9. ↑ Reddy RG, Veeraval L, Maitra S, Chollet-Krugler M, Tomasi S, Dévéhat FL, Boustie J, Chakravarty S. Lichen-derived compounds show potential for central nervous system therapeutics. Phytomedicine. 2016 Nov 15;23(12):1527-1534. doi: 10.1016/j.phymed.2016.08.010. Epub 2016 Aug 31. PMID 27765373.
  • Adenubi OT, Famuyide IM, McGaw LJ, Eloff JN. Lichens: An update on their ethnopharmacological uses and potential as sources of drug leads. J Ethnopharmacol. 2022 Nov 15;298:115657. doi: 10.1016/j.jep.2022.115657. Epub 2022 Aug 22. PMID 36007717.
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