Diarylheptanoïde

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Nom de la substance

Diarylheptanoïde

Famille moléculaire

  • Composé phénolique
    • Les diarylheptanoïdes sont constitués de deux cycles aromatiques reliés par une chaîne de sept carbones portant divers substituants, ils peuvent être linéaires ou cycliques

Source végétale

Propriétés

  • Antioxydants, anti-inflammatoires [1]
  • Protection cellulaire pendant les traitements anticancéreux [2]
  • Activité anti-obésité [3], (gingérénone A) [4]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. ↑ R M Ibrahim S, A Mohamed G, I M Khedr A, M Aljaeid B. Anti-oxidant and Anti-Inflammatory Cyclic Diarylheptanoids from Alnus japonica Stem Bark. Iran J Pharm Res. 2017 Winter;16(Suppl):83-91. PMID: 29844779; PMCID: PMC5963649.
  2. ↑ Dinić J, Ranđelović T, Stanković T, Dragoj M, Isaković A, Novaković M, Pešić M. Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes. Fitoterapia. 2015 Sep;105:169-76. doi: 10.1016/j.fitote.2015.07.003. Epub 2015 Jul 7. PMID 26162555.
  3. ↑ Karri S, Sharma S, Hatware K, Patil K. Natural anti-obesity agents and their therapeutic role in management of obesity: A future trend perspective. Biomed Pharmacother. 2019 Feb;110:224-238. doi: 10.1016/j.biopha.2018.11.076. Epub 2018 Nov 24. PMID 30481727.
  4. ↑ Suk S, Kwon GT, Lee E, Jang WJ, Yang H, Kim JH, Thimmegowda NR, Chung MY, Kwon JY, Yang S, Kim JK, Park JHY, Lee KW. Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice. Mol Nutr Food Res. 2017 Oct;61(10):10.1002/mnfr.201700139. doi: 10.1002/mnfr.201700139. Epub 2017 Jul 20. PMID 28556482; PMCID: PMC5947313.
  • Ganapathy G, Preethi R, Moses JA, Anandharamakrishnan C. Diarylheptanoids as nutraceutical: A review. Biocatal Agric Biotechnol. 2019 May;19:101109. doi: 10.1016/j.bcab.2019.101109. Epub 2019 Mar 26. PMID 32288931; PMCID: PMC7102868
  • Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives - A review. J Tradit Complement Med. 2016 Jun 15;7(2):205-233. doi: 10.1016/j.jtcme.2016.05.005. PMID 28417091; PMCID: PMC5388087.
  • Vidaković V., Novaković M., Popović Z., Janković M., Matić R., Tešević V., Bojović S. Significance of diarylheptanoids for chemotaxonomical distinguishing between Alnus glutinosa and Alnus incana. Holzforschung. 2017;72(1):9–16.
  • Alberti Á, Riethmüller E, Béni S. Characterization of diarylheptanoids: An emerging class of bioactive natural products. J Pharm Biomed Anal. 2018 Jan 5;147:13-34. doi: 10.1016/j.jpba.2017.08.051. Epub 2017 Sep 21. PMID 28958734.