Fucoxanthine
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Nom de la substance
Fucoxanthine
Famille moléculaire
- Pigment caroténoïde époxydé
Source végétale
- Fucus vésiculeux, diatomées (microalgues brunes)
Propriétés
- Activité cytotoxique et antiproliférative sur la plupart des cellules cancéreuses cultivées in vitro [1], [2], [3], [4], [5]
- Phytothérapie de cancers, certaines de ces molécules se dégradent lorsqu’elles sont irradiées par une source LASER et libèrent des molécules toxiques qui peuvent détruire localement les tumeurs [11] par photosensibilisation [12]
Effet thérapeutique
Effets indésirables
Bibliographie
- ↑ Kumar, S. R., Hosokawa, M., & Miyashita, K. (2013). Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms. Marine drugs, 11(12), 5130–5147. https://doi.org/10.3390/md11125130 PMID 24351910
- ↑ Gagez, anne-laure & Thiéry, Valérie & Pasquet, Virginie & Cadoret, Jean-Paul & Picot, Laurent. (2012). Epoxycarotenoids and Cancer. Review. Current Bioactive Compounds. 8. 10.2174/157340712801784787.
- ↑ Luc J Martin. Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment. Mar Drugs. 2015 Jul 31;13(8):4784-98. doi: 10.3390/md13084784. PMID 26264004
- ↑ Jun Wang, Shihui Chen, Shiqiang Xu, Xing Yu, Dongqing Ma, Xiamin Hu, Xiaolu Cao. In Vivo Induction of Apoptosis by Fucoxanthin, a Marine Carotenoid, Associated With Down-Regulating STAT3/EGFR Signaling in Sarcoma 180 (S180) Xenografts-Bearing Mice. Mar Drugs. 2012 Sep;10(9):2055-68. doi: 10.3390/md10092055. PMID 23118721
- ↑ Takayoshi Rokkaku, Ryuichiro Kimura, Chie Ishikawa, Takeshi Yasumoto, Masachika Senba, Fuminori Kanaya, Naoki Mori. Anticancer Effects of Marine Carotenoids, Fucoxanthin and Its Deacetylated Product, Fucoxanthinol, on Osteosarcoma. Int J Oncol. 2013 Oct;43(4):1176-86. doi: 10.3892/ijo.2013.2019. PMID 23857515
- ↑ Yoshiko Satomi. Antitumor and Cancer-preventative Function of Fucoxanthin: A Marine Carotenoid. Anticancer Res. 2017 Apr;37(4):1557-1562. doi: 10.21873/anticanres.11484. PMID 28373414
- ↑ Moreau, D. et al. Cultivated microalgae and the carotenoid fucoxanthin from Odontella aurita as potent anti-proliferative agents in bronchopulmonary and epithelial cell lines. Environ. Toxicol. Pharmacol.22, 97–103 (2006).
- ↑ Kotake-Nara, E., Terasaki, M. & Nagao, A. Characterization of apoptosis induced by fucoxanthin in human promyelocytic leukemia cells. Biosci. Biotechnol. Biochem.69, 224–227 (2005).
- ↑ Eid, S. Y., El-Readi, M. Z. & Wink, M. Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine19, 977–87 (2012).
- ↑ Gagez, A.-L., Thiery, V., Pasquet, V., Cadoret, J.-P. & Picot, L. Epoxycarotenoids and Cancer. Review. Curr. Bioact. Compd.8, 109–141 (2012)
- ↑ Laurent Picot. Lutter contre les cancers grâce aux pigments de microalgues. Biofutur, Elsevier - Cachan : Lavoisier, 2014. hal-01247714
- ↑ Evstigneev VB, Paramonova LI. [Photochemical properties of fucoxanthine]. Biokhimiia (Moscow, Russia), 01 Jan 1976, 41(1):98-103 PMID 1276265