Polydatine
(Redirigé depuis Resvératrol-3-β-mono-D-glucoside)
Nom de la substance
Polydatine, ou picéide = resvératrol-3-β-mono-D-glucoside, resvératrol 3-O-β-D-glucopyranoside
Famille moléculaire
- Stilbénoïde, dérivé du resvératrol (phytoalexine)
Source végétale
Propriétés
- Antioxydant, anti-inflammatoire, neuroprotecteur [1], [2], protecteur vis-à-vis des conséquences de l'ischémie cérébrale dans les accidents vasculaires cérébraux [3]
- Hypolipidémiant [4], [5]
- Hépatoprotecteur [6]
- Améliore la stéatose hépatique non-alcoolique [7]
- Cardioprotecteur [8]
Effet thérapeutique
Effets indésirables
Bibliographie
- ↑ Li RP, Wang ZZ, Sun MX, Hou XL, Sun Y, Deng ZF, Xiao K. Polydatin protects learning and memory impairments in a rat model of vascular dementia. Phytomedicine. 2012 Jun 15;19(8-9):677-81. doi: 10.1016/j.phymed.2012.03.002. PMID 22483554.
- ↑ Fakhri S, Gravandi MM, Abdian S, Akkol EK, Farzaei MH, Sobarzo-Sánchez E. The Neuroprotective Role of Polydatin: Neuropharmacological Mechanisms, Molecular Targets, Therapeutic Potentials, and Clinical Perspective. Molecules. 2021 Oct 2;26(19):5985. doi: 10.3390/molecules26195985. PMID 34641529; PMCID: PMC8513080.
- ↑ Tang KS, Tan JS. The protective mechanisms of polydatin in cerebral ischemia. Eur J Pharmacol. 2019 Jan 5;842:133-138. doi: 10.1016/j.ejphar.2018.10.039. PMID 30385347.
- ↑ Xing WW, Wu JZ, Jia M, Du J, Zhang H, Qin LP. Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits. Biomed Pharmacother. 2009 Aug;63(7):457-62. doi: 10.1016/j.biopha.2008.06.035. PMID 18657948.
- ↑ Du J, Sun LN, Xing WW, Huang BK, Jia M, Wu JZ, Zhang H, Qin LP. Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters. Phytomedicine. 2009 Jun;16(6-7):652-8. doi: 10.1016/j.phymed.2008.10.001. PMID 19106037.
- ↑ Karami A, Fakhri S, Kooshki L, Khan H. Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits. Molecules. 2022 Oct 1;27(19):6474. doi: 10.3390/molecules27196474. PMID 36235012; PMCID: PMC9572446.
- ↑ Zhang J, Tan Y, Yao F, Zhang Q. Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c. Mol Med Rep. 2012 Oct;6(4):815-20. doi: 10.3892/mmr.2012.1015. PMID 22858825.
- ↑ Deng J, Liu W, Wang Y, Dong M, Zheng M, Liu J. Polydatin modulates Ca(2+) handling, excitation-contraction coupling and β-adrenergic signaling in rat ventricular myocytes. J Mol Cell Cardiol. 2012 Nov;53(5):646-56. doi: 10.1016/j.yjmcc.2012.08.009. PMID 22921781.