Thuyanol
(Redirigé depuis Thujanol)
Nom de la substance
Thuyanol, thujanol, 4-thujanol, thuyanol-4, thujanol-4
- cis-thuyanol-4, cis-4-thuyanol = cis-sabinène hydrate, hydrate de cis-sabinène, (Z)-sabinène hydrate, (Z)-hydrate de sabinène
- trans-thuyanol-4, trans-4-thuyanol = trans-sabinène hydrate, hydrate de trans-sabinène, (E)-sabinène hydrate, (E)-hydrate de sabinène
Famille moléculaire
Alcool monoterpénique bicyclique
Source végétale
- Huile essentielle de marjolaine, sarriette, serpolet, thym ct thuyanol (= thym à thuyanol), Pituranthos tortuosus
Propriétés
- Effet anti-infectieux [1]
- Présenté comme immunostimulant (stimulerait la production des Ig A), inducteur d'apoptose (?) [2]
- Protège de la toxicité rénale et hépatique de l'acétate de plomb [3], et de la toxicité de certains médicaments anticancéreux [4]
- Antioxydant, diminue la peroxydation des lipides, l'hydrate de sabinène agit sur la prévention de la formation de peroxyde pendant le stockage des huiles alimentaires [5]
Effet thérapeutique
Effets indésirables
- Non cytotoxique ni génotoxique [6], mais une autre étude signale que le 4-thujanol a un effet clastogène significatif, donc génotoxique [7]
Bibliographie
- ↑ Schmidt E, Wanner J, Hiiferl M, Jirovetz L, Buchbauer G, Gochev V, Girova T, Stoyanova A, Geissler M. Chemical composition, olfactory analysis and antibacterial activity of Thymus vulgaris chemotypes geraniol, 4-thujanol/terpinen-4-ol, thymol and linalool cultivated in southern France. Nat Prod Commun. 2012 Aug;7(8):1095-8. PMID 22978238
- ↑ Krifa M, El Mekdad H, Bentouati N, Pizzi A, Ghedira K, Hammami M, El Meshri SE, Chekir-Ghedira L. Immunomodulatory and anticancer effects of Pituranthos tortuosus essential oil. Tumour Biol. 2015 Jul;36(7):5165-70. doi: 10.1007/s13277-015-3170-3. PMID 25663463
- ↑ Ibrahim M. El-Ashmawy, Abeer F. El-Nahas, Osama M. Salama. Protective Effect of Volatile Oil, Alcoholic and Aqueous Extracts of Origanum majorana on Lead Acetate Toxicity in Mice. Basic & Clinical Pharmacology & Toxicology, Volume 97, Issue 4, pages 238–243, October 2005. [1]
- ↑ Kocaman AY, Istifli ES, Büyükleyla M, Rencüzogullari E, Topaktaş M. In vitro evaluation of the protective effects of 4-thujanol against mitomycin-C and cyclophosphamide-induced genotoxic damage in human peripheral lymphocytes. Toxicol Ind Health. 2013 Feb;29(1):23-37. PMID 22323477
- ↑ Quiroga PR, Asensio CM, Nepote V. Antioxidant effects of the monoterpenes carvacrol, thymol and sabinene hydrate on chemical and sensory stability of roasted sunflower seeds. J Sci Food Agric. 2015 Feb;95(3):471-9. doi: 10.1002/jsfa.6744. PMID 24841286
- ↑ Kocaman AY, Rencüzoğulları E, Topaktaş M, Istifli ES, Büyükleyla M. The effects of 4-thujanol on chromosome aberrations, sister chromatid exchanges and micronucleus in human peripheral blood lymphocytes. Cytotechnology. 2011 Oct;63(5):493-502. PMID 21735266
- ↑ Kocaman AY, Rencüzoğulları E, Topaktaş M, Istifli ES, Büyükleyla M. The effects of 4-thujanol on chromosome aberrations, sister chromatid exchanges and micronucleus in human peripheral blood lymphocytes. Cytotechnology. 2011 Oct;63(5):493-502. doi: 10.1007/s10616-011-9372-7. PMID 21735266; PMCID: PMC3176937.
- Bhatia SP, Letizia CS, Api AM. Fragrance material review on 4-thujanol. Food Chem Toxicol. 2008 Nov;46 Suppl 11:S295-6. PMID 18640194
- Johannes Novak, Christina Bitsch, Jan Langbehn, Friedrich Pank, Melpo Skoula, Yiota Gotsiou, Chlodwig M. Franz. Ratios of cis- and trans-Sabinene Hydrate in Origanum majorana L. and Origanum microphyllum (Bentham) Vogel. Biochemical Systematics and Ecology, Volume 28, Issue 7, August 2000, Pages 697-704
- Thompson JD, Chalchat JC, Michet A, Linhart YB, Ehlers B. Qualitative and quantitative variation in monoterpene co-occurrence and composition in the essential oil of Thymus vulgaris chemotypes. J Chem Ecol. 2003 Apr;29(4):859-80. PMID 12775148