Échinacoside

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Nom de la substance

Échinacoside

Famille moléculaire

Composé phénolique (glycoside de phényléthanoïde)

Source végétale

Propriétés

  • Anti-inflammatoire, améliore la dysfonction mitochondriale et protège les neurones dopaminergiques [1]
  • Neuroprotecteur [2], [3], potentialités dans les maladies de Parkinson [4], [5] et d’Alzheimer [6]
  • Hépatoprotecteur [7]
  • Inducteur d'apoptose dans certaines cellules de cancer du colon [8] et du sein [9], [10]
  • Anti-ostéoporotique sur modèle murin [11], [12], prévention de l’ostéoporose induite par l’ovariectomie chez le rat femelle [13]
  • Action vasodilatatrice de l'aorte de rat par effet sur l'endothélium vasculaire [14]
  • Antiviral [15]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Wang, Y.-H., Xuan, Z.-H., Tian, S., & Du, G.-H. (2015). Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production. Evidence-Based Complementary and Alternative Medicine : eCAM, 2015, 189239. http://doi.org/10.1155/2015/189239
  2. More, S. V., Kumar, H., Kang, S. M., Song, S.-Y., Lee, K., & Choi, D.-K. (2013). Advances in Neuroprotective Ingredients of Medicinal Herbs by Using Cellular and Animal Models of Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine : eCAM, 2013, 957875. http://doi.org/10.1155/2013/957875 texte intégral
  3. Kuang R, Sun Y, Yuan W, Lei L, Zheng X. Protective effects of echinacoside, one of the phenylethanoid glycosides, on H(2)O(2)-induced cytotoxicity in PC12 cells. Planta Med. 2009 Nov;75(14):1499-504. doi: 10.1055/s-0029-1185806. PMID 19548189
  4. Geng, X., Tian, X., Tu, P., & Pu, X. (2007). Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson's disease. European Journal of Pharmacology, 564(1-3), 66-74.
  5. Zhao, Q., Gao, J., Li, W., & Cai, D. (2010). Neurotrophic and neurorescue effects of Echinacoside in the subacute MPTP mouse model of Parkinson's disease. Brain research, 1346, 224-236.
  6. Liu J, Yang L, Dong Y, Zhang B, Ma X. Echinacoside, an Inestimable Natural Product in Treatment of Neurological and other Disorders. Molecules. 2018; 23(5):1213. https://doi.org/10.3390/molecules23051213
  7. Wu, Y., Li, L., Wen, T., & Li, Y. Q. (2007). Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats. Toxicology, 232(1-2), 50-56.
  8. Dong, L., Yu, D., Wu, N., Wang, H., Niu, J., Wang, Y., & Zou, Z. (2015). Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages. International Journal of Molecular Sciences, 16(7), 14655–14668. http://doi.org/10.3390/ijms160714655
  9. Tang C, Gong L, Lvzi Xu, Qiu K, Zhang Z, Wan L. Echinacoside inhibits breast cancer cells by suppressing the Wnt/β-catenin signaling pathway. Biochem Biophys Res Commun. 2020 May 21;526(1):170-175. doi: 10.1016/j.bbrc.2020.03.050. PMID 32201078.
  10. Bian P, Liu C, Hu W, Ding Y, Qiu S, Li L. Echinacoside Suppresses the Progression of Breast Cancer by Downregulating the Expression of miR-4306 and miR-4508. Integr Cancer Ther. 2021 Jan-Dec;20:15347354211062639. doi: 10.1177/15347354211062639. PMID 34903085
  11. Yang X, Li F, Yang Y, et al. Efficacy and Safety of Echinacoside in a Rat Osteopenia Model. Evidence-based Complementary and Alternative Medicine : eCAM. 2013;2013:926928. doi:10.1155/2013/926928.
  12. Li, F., Yang, Y., Zhu, P., Chen, W., Qi, D., Shi, X., ... & Li, P. (2012). Echinacoside promotes bone regeneration by increasing OPG/RANKL ratio in MC3T3-E1 cells. Fitoterapia, 83(8), 1443-1450.
  13. Li, F., Yang, X., Yang, Y., Guo, C., Zhang, C., Yang, Z., & Li, P. (2013). Antiosteoporotic activity of echinacoside in ovariectomized rats. Phytomedicine, 20(6), 549-557.
  14. He WJ, Fang TH, Ma X, Zhang K, Ma ZZ, Tu PF. Echinacoside elicits endothelium-dependent relaxation in rat aortic rings via an NO-cGMP pathway. Planta Med. 2009 Oct;75(13):1400-4. doi: 10.1055/s-0029-1185745. PMID 19468974
  15. Wu L, Georgiev MI, Cao H, Nahar L, El-Seedi HR, Sarker SD, Xiao J, Lu B. Therapeutic potential of phenylethanoid glycosides: A systematic review. Med Res Rev. 2020 Nov;40(6):2605-2649. doi: 10.1002/med.21717. PMID 32779240.
  • Jia C, Shi H, Wu X, Li Y, Chen J, Tu P. Determination of echinacoside in rat serum by reversed-phase high-performance liquid chromatography with ultraviolet detection and its application to pharmacokinetics and bioavailability. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Dec 5;844(2):308-13. PMID 16931184