Béta-élémène

De WikiPhyto

Nom de la substance

Béta-élémène

Famille moléculaire

hydrocarbure sesquiterpénique

Source végétale

Propriétés

  • Propriétés anticancéreuses [1], [2], [3], [4], [5], [6], induit l'activité des caspase-3, -7, -9, diminue l'expression de Bcl-2, entraine la libération de cytochrome c et augmente la concentration de caspase-9 et de poly(ADP-ribose) polymérase (dans cellules NSCLC épithéliales bronchiques et fibroblastiques de la langue), inhibe la prolifération des cellules de cancer ovarien résistantes au cis-platine, forte synergie avec le cis-platine [7], inducteur d'apoptose, agit dans les leucémies et les tumeurs solides, cancer du poumon (NSCLC), lignées cellulaires H460 et A549, en synergie avec le cis-platine [8], cancer de la prostate [9], antitumoral dans cancers du poumon et du colon [10]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Wang G, Li X, Huang F, Zhao J, Ding H, Cunningham C, Coad JE, Flynn DC, Reed E, Li QQ. Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. Cell Mol Life Sci. 2005 Apr;62(7-8):881-93. PMID 15868411
  2. Zhao J, Li QQ, Zou B, Wang G, Li X, Kim JE, Cuff CF, Huang L, Reed E, Gardner K. In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma. Int J Oncol. 2007 Aug;31(2):241-52.
  3. Edris AE. Anti-cancer properties of Nigella spp. Essential oils and their major constituents, thymoquinone and beta-elemene. Curr Clin Pharmacol. 2009 Jan;4(1):43-6. PMID 19149500
  4. Yu Z, Wang R, Xu L, Dong J, Jing Y. N-(beta-Elemene-13-yl)tryptophan methyl ester induces apoptosis in human leukemia cells and synergizes with arsenic trioxide through a hydrogen peroxide dependent pathway. Cancer Lett. 2008 Sep 28;269(1):165-73.
  5. Yao YQ, Ding X, Jia YC, Huang CX, Wang YZ, Xu YH. Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation. Cancer Lett. 2008 Jun 8;264(1):127-34.
  6. Dai ZJ, Tang W, Lu WF, Gao J, Kang HF, Ma XB, Min WL, Wang XJ, Wu WY. Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells. Cancer Cell Int. 2013 Mar 14;13(1):27. doi: 10.1186/1475-2867-13-27. PMID 23496852 texte intégral
  7. Li X, Wang G, Zhao J, Ding H, Cunningham C, Chen F, Flynn DC, Reed E, Li QQ. Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase. Cell Mol Life Sci. 2005 Apr;62(7-8):894-904. PMID 15868412
  8. Li QQ, Wang G, Zhang M, Cuff CF, Huang L, Reed E. beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis. Oncol Rep. 2009 Jul;22(1):161-70. PMID 19513519
  9. Li QQ, Wang G, Huang F, Banda M, Reed E. Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells. J Pharm Pharmacol. 2010 Aug;62(8):1018-27. doi: 10.1111/j.2042-7158.2010.01135.x. PMID 20663036
  10. Sylvestre M, Pichette A, Longtin A, Nagau F, Legault J. Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe. J Ethnopharmacol. 2006 Jan 3;103(1):99-102. PMID 16168586
  • Peng X, Zhao Y, Liang X, Wu L, Cui S, Guo A, Wang W. Assessing the quality of RCTs on the effect of beta-elemene, one ingredient of a Chinese herb, against malignant tumors. Contemp Clin Trials. 2006 Feb;27(1):70-82. PMID 16243588