Diarylheptanoïde

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Nom de la substance

Diarylheptanoïde

Famille moléculaire

  • Composé phénolique
    • Les diarylheptanoïdes sont constitués de deux cycles aromatiques reliés par une chaîne de sept carbones portant divers substituants, ils peuvent être linéaires ou cycliques

Source végétale

Propriétés

  • Antioxydants, anti-inflammatoires [1]
  • Protection cellulaire pendant les traitements anticancéreux [2]
  • Activité anti-obésité [3], (gingérénone A) [4]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. R M Ibrahim S, A Mohamed G, I M Khedr A, M Aljaeid B. Anti-oxidant and Anti-Inflammatory Cyclic Diarylheptanoids from Alnus japonica Stem Bark. Iran J Pharm Res. 2017 Winter;16(Suppl):83-91. PMID: 29844779; PMCID: PMC5963649.
  2. Dinić J, Ranđelović T, Stanković T, Dragoj M, Isaković A, Novaković M, Pešić M. Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes. Fitoterapia. 2015 Sep;105:169-76. doi: 10.1016/j.fitote.2015.07.003. Epub 2015 Jul 7. PMID 26162555.
  3. Karri S, Sharma S, Hatware K, Patil K. Natural anti-obesity agents and their therapeutic role in management of obesity: A future trend perspective. Biomed Pharmacother. 2019 Feb;110:224-238. doi: 10.1016/j.biopha.2018.11.076. Epub 2018 Nov 24. PMID 30481727.
  4. Suk S, Kwon GT, Lee E, Jang WJ, Yang H, Kim JH, Thimmegowda NR, Chung MY, Kwon JY, Yang S, Kim JK, Park JHY, Lee KW. Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice. Mol Nutr Food Res. 2017 Oct;61(10):10.1002/mnfr.201700139. doi: 10.1002/mnfr.201700139. Epub 2017 Jul 20. PMID 28556482; PMCID: PMC5947313.
  • Ganapathy G, Preethi R, Moses JA, Anandharamakrishnan C. Diarylheptanoids as nutraceutical: A review. Biocatal Agric Biotechnol. 2019 May;19:101109. doi: 10.1016/j.bcab.2019.101109. Epub 2019 Mar 26. PMID 32288931; PMCID: PMC7102868
  • Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives - A review. J Tradit Complement Med. 2016 Jun 15;7(2):205-233. doi: 10.1016/j.jtcme.2016.05.005. PMID 28417091; PMCID: PMC5388087.
  • Vidaković V., Novaković M., Popović Z., Janković M., Matić R., Tešević V., Bojović S. Significance of diarylheptanoids for chemotaxonomical distinguishing between Alnus glutinosa and Alnus incana. Holzforschung. 2017;72(1):9–16.
  • Alberti Á, Riethmüller E, Béni S. Characterization of diarylheptanoids: An emerging class of bioactive natural products. J Pharm Biomed Anal. 2018 Jan 5;147:13-34. doi: 10.1016/j.jpba.2017.08.051. Epub 2017 Sep 21. PMID 28958734.