Fucoxanthine

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Nom de la substance

Fucoxanthine

Famille moléculaire

Source végétale

Propriétés

  • Activité cytotoxique et antiproliférative sur la plupart des cellules cancéreuses cultivées in vitro [1], [2], [3], [4], [5]

[6], [7], [8], [9], [10]

  • Phytothérapie de cancers, certaines de ces molécules se dégradent lorsqu’elles sont irradiées par une source LASER et libèrent des molécules toxiques qui peuvent détruire localement les tumeurs [11] par photosensibilisation [12]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Kumar, S. R., Hosokawa, M., & Miyashita, K. (2013). Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms. Marine drugs, 11(12), 5130–5147. https://doi.org/10.3390/md11125130 PMID 24351910
  2. Gagez, anne-laure & Thiéry, Valérie & Pasquet, Virginie & Cadoret, Jean-Paul & Picot, Laurent. (2012). Epoxycarotenoids and Cancer. Review. Current Bioactive Compounds. 8. 10.2174/157340712801784787.
  3. Luc J Martin. Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment. Mar Drugs. 2015 Jul 31;13(8):4784-98. doi: 10.3390/md13084784. PMID 26264004
  4. Jun Wang, Shihui Chen, Shiqiang Xu, Xing Yu, Dongqing Ma, Xiamin Hu, Xiaolu Cao. In Vivo Induction of Apoptosis by Fucoxanthin, a Marine Carotenoid, Associated With Down-Regulating STAT3/EGFR Signaling in Sarcoma 180 (S180) Xenografts-Bearing Mice. Mar Drugs. 2012 Sep;10(9):2055-68. doi: 10.3390/md10092055. PMID 23118721
  5. Takayoshi Rokkaku, Ryuichiro Kimura, Chie Ishikawa, Takeshi Yasumoto, Masachika Senba, Fuminori Kanaya, Naoki Mori. Anticancer Effects of Marine Carotenoids, Fucoxanthin and Its Deacetylated Product, Fucoxanthinol, on Osteosarcoma. Int J Oncol. 2013 Oct;43(4):1176-86. doi: 10.3892/ijo.2013.2019. PMID 23857515
  6. Yoshiko Satomi. Antitumor and Cancer-preventative Function of Fucoxanthin: A Marine Carotenoid. Anticancer Res. 2017 Apr;37(4):1557-1562. doi: 10.21873/anticanres.11484. PMID 28373414
  7. Moreau, D. et al. Cultivated microalgae and the carotenoid fucoxanthin from Odontella aurita as potent anti-proliferative agents in bronchopulmonary and epithelial cell lines. Environ. Toxicol. Pharmacol.22, 97–103 (2006).
  8. Kotake-Nara, E., Terasaki, M. & Nagao, A. Characterization of apoptosis induced by fucoxanthin in human promyelocytic leukemia cells. Biosci. Biotechnol. Biochem.69, 224–227 (2005).
  9. Eid, S. Y., El-Readi, M. Z. & Wink, M. Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine19, 977–87 (2012).
  10. Gagez, A.-L., Thiery, V., Pasquet, V., Cadoret, J.-P. & Picot, L. Epoxycarotenoids and Cancer. Review. Curr. Bioact. Compd.8, 109–141 (2012)
  11. Laurent Picot. Lutter contre les cancers grâce aux pigments de microalgues. Biofutur, Elsevier - Cachan : Lavoisier, 2014. hal-01247714
  12. Evstigneev VB, Paramonova LI. [Photochemical properties of fucoxanthine]. Biokhimiia (Moscow, Russia), 01 Jan 1976, 41(1):98-103 PMID 1276265