Lentinane

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Nom de la substance

Lentinane

Famille moléculaire

Polysaccharide du β 1-3, glycane

Source végétale

Shii-Také Lentinus edodes

Propriétés

Effet thérapeutique

  • Accompagnement des cancers en traitement adjuvants
    • Des études rapportent des cas de rémission complète de cancers de l'estomac avec métastases hépatiques par l'association lentinane avec Tégafur®, une prodrogue du 5-FU [5], [6] ou d'autres protocoles de chimiothérapie [7]
  • Maladies inflammatoires chroniques de l'intestin (MICI) [8], [9], [10]

Effets indésirables

  • Réactions allergiques possibles (sensibilité préalable aux champignons)

Bibliographie

  1. ↑ Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29. PMID 10702635
  2. ↑ Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol. 2002 Nov;60(3):258-74. PMID 12436306
  3. ↑ Jiao Shen, Jia-fei Yao, Mamoru Tanida, Yuko HoriietKatsuya Nagai. An Evidence-based Perspective of Lentinus Edodes (Shiitake Mushroom) for Cancer Patients. Evidence-based Anticancer Materia Medica, Evidence-based Anticancer Complementary and Alternative Medicine, 2011, 303-317, [1]
  4. ↑ Yap AT, Ng ML. Immunopotentiating properties of lentinan (1-3)- β-d-glucan extracted from culinary-medicinal Shiitake mushroom Lentinus edodes (Berk.) Singer (Agaricomycetidae) Int J Med Mushrooms. 2003;5:339–58.
  5. ↑ Wada T. Case of complete response of liver metastasis of gastric cancer treated by lentinan plus tegafur Yakuri to chiryo A. 1988, vol. 16, n° 4, pp. 437-440
  6. ↑ Takahashi T, Hori Y, Isogawa S, Saho M, Yoshida H, Yokoyama K, Watanabe M, Nakagawa S. A case of hepatocellular carcinoma in an elderly patient that improved upon combination therapy of Lentinan and Tegafur. Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 1):1517-9. PMID 1697155
  7. ↑ Miyamoto K, Inagaki Y, Miyairi M. [Successful therapy with tegafur and lentinan after TAE for hepatocellular carcinoma--a case report]. Nihon Gan Chiryo Gakkai Shi. 1989 Dec 20;24(11):2624-8. PMID 2559131
  8. ↑ Nishitani Y, Zhang L, Yoshida M, Azuma T, Kanazawa K, Hashimoto T, Mizuno M. Intestinal anti-inflammatory activity of lentinan: influence on IL-8 and TNFR1 expression in intestinal epithelial cells. PLoS One. 2013 Apr 22;8(4):e62441. doi: 10.1371/journal.pone.0062441. Print 2013. PMID 23630633
  9. ↑ Mizuno M, Nishitani Y, Hashimoto T, Kanazawa K. Different suppressive effects of fucoidan and lentinan on IL-8 mRNA expression in in vitro gut inflammation. Biosci Biotechnol Biochem. 2009 Oct;73(10):2324-5. PMID 19809164
  10. ↑ Tanoue T, Nishitani Y, Kanazawa K, Hashimoto T, Mizuno M. In vitro model to estimate gut inflammation using co-cultured Caco-2 and RAW264.7 cells. Biochem Biophys Res Commun. 2008 Sep 26;374(3):565-9. doi: 10.1016/j.bbrc.2008.07.063. PMID 18647595
  • Hesham El Enshasy. The Mycota Volume 10, 2010, pp 165-194
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