Lycopène

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Nom de la substance

Lycopène

Famille moléculaire

Tétraterpène (caroténoïde)

Source végétale

Propriétés

  • Anti-oxydant, capable de neutraliser l'oxygène singulet, protecteur rétinien
  • Sa consommation est associée à un moindre risque cardio-vasculaire [1], [2]
  • Réduction du risque de cancer, surtout de la prostate [3], [4], [5], [6], [7], [8], [9], [10], [11]
  • La biodisponibilité du lycopène dans les concentrés de tomate ou le ketchup est plus importante que celle des tomates fraîches [12], [13]
  • Protection vis-à-vis de certaines chimiothérapies, réduction de la toxicité myocardique induite par la doxorubicine [14]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. ↑ Sesso HD, Buring JE, Norkus EP, Gaziano JM. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women. Am J Clin Nutr. 2004 Jan;79(1):47-53. PMID 14684396
  2. ↑ Kohlmeier L, Kark JD, Gomez-Gracia E, Martin BC, Steck SE, Kardinaal AF, Ringstad J, Thamm M, Masaev V, Riemersma R, Martin-Moreno JM, Huttunen JK, Kok FJ. Lycopene and myocardial infarction risk in the EURAMIC Study. Am J Epidemiol. 1997 Oct 15;146(8):618-26. PMID 9345115
  3. ↑ Haseen F, Cantwell MM, O'Sullivan JM, Murray LJ. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic Dis. 2009;12(4):325-32. PMID 19901932
  4. ↑ Stacewicz-Sapuntzakis M, Bowen PE. Role of lycopene and tomato products in prostate health. Biochim Biophys Acta. 2005 May 30;1740(2):202-5. PMID 15949687
  5. ↑ Giovannucci, E., Rimm, E. B., Liu, Y., Stampfer, M. J., & Willett, W. C. (2002). A prospective study of tomato products, lycopene, and prostate cancer risk. Journal of the National Cancer Institute, 94(5), 391-398.
  6. ↑ Giovannucci, E., & Clinton, S. K. (1998). Tomatoes, lycopene, and prostate cancer. Proceedings of the Society for Experimental Biology and Medicine, 218(2), 129-139.
  7. ↑ Giovannucci, E. (2005). Tomato products, lycopene, and prostate cancer: a review of the epidemiological literature. The Journal of nutrition, 135(8), 2030S-2031S.
  8. ↑ Giovannucci, E. (2002). A review of epidemiologic studies of tomatoes, lycopene, and prostate cancer. Experimental biology and medicine, 227(10), 852-859.
  9. ↑ Wei, M. Y., & Giovannucci, E. L. (2012). Lycopene, tomato products, and prostate cancer incidence: a review and reassessment in the PSA screening era. Journal of oncology, 2012.
  10. ↑ Michaud, D. S., Feskanich, D., Rimm, E. B., Colditz, G. A., Speizer, F. E., Willett, W. C., & Giovannucci, E. (2000). Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts. The American journal of clinical nutrition, 72(4), 990-997.
  11. ↑ Giovannucci, E. (1999). Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. Journal of the national cancer institute, 91(4), 317-331.
  12. ↑ Gärtner, C., Stahl, W., & Sies, H. (1997). Lycopene is more bioavailable from tomato paste than from fresh tomatoes. The American journal of clinical nutrition, 66(1), 116-122.
  13. ↑ Rao, A. V., Waseem, Z., & Agarwal, S. (1998). Lycopene content of tomatoes and tomato products and their contribution to dietary lycopene. Food Research International, 31(10), 737-741.
  14. ↑ Anjos Ferreira AL, Russell RM, Rocha N, Placido Ladeira MS, Favero Salvadori DM, Oliveira Nascimento MC, Matsui M, Carvalho FA, Tang G, Matsubara LS, Matsubara BB. Effect of lycopene on doxorubicin-induced cardiotoxicity: an echocardiographic, histological and morphometrical assessment. Basic Clin Pharmacol Toxicol. 2007 Jul;101(1):16-24. PMID 17577311
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