Lycorine

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Nom de la substance

Lycorine = amarylline = galanthidine = narcissine

Famille moléculaire

Source végétale

Propriétés

  • Propriétés multiples : anti-tumorales [1], anti-angiogéniques, antileucémiques, sur cellules de myélome multiple ARH-77 [2], antivirales, antibactériennes, anti-inflammatoires, antipaludéennes [3]
  • Hypotenseur [4]
  • Antiviral vis-à-vis du SARS-CoV, intérêt dans le traitement du COVID [5]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Lamoral-Theys D, Decaestecker C, Mathieu V, Dubois J, Kornienko A, Kiss R, Evidente A, Pottier L. Lycorine and its derivatives for anticancer drug design. Mini Rev Med Chem. 2010 Jan;10(1):41-50. PMID 20105122
  2. Luo, Y., Roy, M., Xiao, X. et al. Lycorine induces programmed necrosis in the multiple myeloma cell line ARH-77. Tumor Biol. 36, 2937–2945 (2015). https://doi.org/10.1007/s13277-014-2924-7
  3. Cao, Z., Yang, P. & Zhou, Q. Multiple biological functions and pharmacological effects of lycorine. Sci. China Chem. 56, 1382–1391 (2013). https://doi.org/10.1007/s11426-013-4967-9
  4. Miyasaka K, Hiramatsu Y. Pharmacological studies of lycorenine, an alkaloid of Lycoris radiata Herb.: II. Effects of blood pressure in rats and dogs and the mechanism of tachyphylaxis to the vasodepressor action of lycorenine in rats. Jpn J Pharmacol. 1980 Oct;30(5):655-64. PMID 6110797
  5. Li SY, Chen C, Zhang HQ, Guo HY, Wang H, Wang L, Zhang X, Hua SN, Yu J, Xiao PG, Li RS, Tan X. Identification of natural compounds with antiviral activities against SARS-associated coronavirus. Antiviral Res. 2005 Jul;67(1):18-23. PMID 15885816
  • Ali, A.A., Kating, H., Frahm, A.W., El-moghazi, A.M., Ramadan, M.A., 1981. Two non-hydroxylated alkaloids in Crinum augustum. Phytochemistry 20, 1121–1123