Nobilétine

De WikiPhyto

Nom de la substance

Nobilétine

Famille moléculaire

Flavonoïde (flavone polyméthoxylée)

Source végétale

Propriétés

  • Anti-inflammatoire [1], [2]
  • Anti-oxydant, inhibe la promotion tumorale [3]
  • Hypocholestérolémiante
  • Anti-tumorale, inhibe la carcinogenèse [4], inhibe la mutagénèse induite par des cancérigènes, inhibe la division des cellules cancéreuses [5]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Lin N, Sato T, Takayama Y et al. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem Pharmacol 2003 June 15;65(12):2065-71. PMID 12787887
  2. Murakami A, Nakamura Y, Torikai K et al. Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice. Cancer Res 2000 September 15;60(18):5059-66. PMID 11016629
  3. Nakamura Y, Murakami A, Ohigashi H. Search for Naturally-occurring Antioxidative Chemopreventors on the Basis of the Involvement of Leukocyte-derived Reactive Oxygen Species in Carcinogenesis. Asian Pac J Cancer Prev. 2000;1(2):115-120. PMID 12718677
  4. Suzuki R, Kohno H, Murakami A et al. Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats. Biofactors 2004;22(1-4):111-4. PMID 15751122
  5. Ohnishi H, Asamoto M, Tujimura K, Hokaiwado N, Takahashi S, Ogawa K, Kuribayashi M, Ogiso T, Okuyama H, Shirai T. Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo. Cancer Sci. 2004 Dec;95(12):936-42. PMID 15596041
  • Edeas M. Citroflavonoïdes. Revue Phytothérapie. Vol 5, N° 4, oct 2007 [1]