Flavonoïdes

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Nom de la substance

Flavonoïdes

Famille moléculaire

Source végétale

  • Fruits, légumes, vin, thé, quasiment toutes les plantes médicinales
  • Teneur en nutriments protecteurs de quelques légumes (en mg/100 g)
	Fibres solubles F.insolubles	Vitamine C	Caroténoïdes	Flavonoïdes*
brocoli		15		14	90-149		3		10
céleri		12,6		15,3	75		2		10
chicorée	9,9		12,8	15		2		2
choux Bruxelles	6,3		14,3	70		1,8		6,5
chou fleur	12		13,4	50		0,3		0,3
concombre	6,6		10,2	20		2		0,2
endive		9,2		11,5	20		1,3		29
épinards	7,6		13,3	50		15		0,1
haricots verts	12,8		17,4	20		3		7
laitue		11,3		12,5	20		3		1,5
oignon		11,6		9,5	15		0,3		35
poireau		12,6		12,5	25		3		10
radis		11,3		15,9	25		0,2		0,6
---
(*quercétine + kaempférol + apigénine + lutéoline)

Source : Marie-José Amiot-Carlin et Christian Rémésy (INRA) [5]

Propriétés

Effet thérapeutique

  • Réduction de nombreuses maladies chroniques de civilisation, cancers, maladies cardio-vasculaires et cérébro-vasculaires, diabète [28]
  • Prévention de la survenue de maladie de Parkinson (surtout avec les anthocyanes des petits fruits colorés [29], [30]

Effets indésirables

  • Interactions potentielles avec les cytochromes P450 [31], [32]


Bibliographie

  1. USDA Database for the Flavonoid: http://www.nal.usda.gov/fnic/foodcomp/Data/Flav/Flav02-1.pdf
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  5. Actis-Goretta L, Ottaviani JI, Keen CL, Fraga CG. Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins. FEBS Lett. 2003 Dec 18;555(3):597-600. PMID 14675780
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  10. Szliszka E, Czuba ZP, Mazur B, Paradysz A, Krol W. Chalcones and dihydrochalcones augment TRAIL-mediated apoptosis in prostate cancer cells. Molecules. 2010 Aug 4;15(8):5336-53. PMID 20714300
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  12. Bédard Valérie. Les propriétés anti-angiogéniques des flavonoïdes. Mémoire de maîtrise en chimie. Université du Québec à Montréal, avril 2008
  13. Kim YH, Shin EK, Kim DH, Lee HH, Park JH, Kim JK. Antiangiogenic effect of licochalcone A. Biochem Pharmacol. 2010 Oct 15;80(8):1152-9. PMID 20637733
  14. Gacche RN, Shegokar HD, Gond DS, Yang Z, Jadhav AD. Evaluation of selected flavonoids as antiangiogenic, anticancer, and radical scavenging agents: an experimental and in silico analysis. Cell Biochem Biophys. 2011 Dec;61(3):651-63. PMID 21830125
  15. Amin AR, Wang D, Zhang H, Peng S, Shin HJ, Brandes JC, Tighiouart M, Khuri FR, Chen ZG, Shin DM. Enhanced anti-tumor activity by the combination of the natural compounds (-)-epigallocatechin-3-gallate and luteolin: potential role of p53. J Biol Chem. 2010 Nov 5;285(45):34557-65. PMID 20826787
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