Élémène

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Nom de la substance

Élémène

Famille moléculaire

Hydrocarbure sesquiterpénique

Source végétale

Propriétés

Effet thérapeutique

  • Améliore la qualité de vie des patients atteints de gliome malin

Effets indésirables

  • DL 50 par voie orale chez la souris supérieure à 5000 mg/kg PubChem

Bibliographie

  1. Yang H, Wang X, Yu L. The antitumor activity of elemene is associated with apoptosis. Zhonghua Zhong Liu Za Zhi. 1996. PMID 9387246
  2. Zheng S, Yang H, Zhang S, Wang X, Yu L, Lu J, Li J. Initial study on naturally occurring products from traditional Chinese herbs and vegetables for chemoprevention. J Cell Biochem Suppl. 1997;27:106-12. PMID 9591200
  3. Aggarwal BB, Yuan W, Li S, Gupta SC. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013 Sep;57(9):1529-42. doi: 10.1002/mnfr.201200838. PMID 23847105
  4. Liu JS, He SC, Zhang ZL, Chen R, Fan L, Qiu GL, Chang S, Li L, Che XM. Anticancer effects of β-elemene in gastric cancer cells and its potential underlying proteins: A proteomic study. Oncol Rep. 2014 Dec;32(6):2635-47. doi: 10.3892/or.2014.3490. PMID 25333415
  5. Chen J, Chen YJ, Wu MD. Herbal extract elemene intrathoracic injection in the treatment of lung cancer patients with malignant pleural effusion: a meta-anaylsis. J Cancer Res Ther. 2014 Aug;10 Suppl 1:56-9. doi: 10.4103/0973-1482.139761. PMID 25207893
  6. Lin Y, Wang K, Hu C, Lin L, Qin S, Cai X. Elemene injection induced autophagy protects human hepatoma cancer cells from starvation and undergoing apoptosis. Evid Based Complement Alternat Med. 2014;2014:637528. doi: 10.1155/2014/637528. PMID 25152762
  7. Guan C, Liu W, Yue Y, Jin H, Wang X, Wang XJ. Inhibitory effect of β-elemene on human breast cancer cells. Int J Clin Exp Pathol. 2014 Jun 15;7(7):3948-56. eCollection 2014. PMID 25120771
  8. Yuan J, Gu ZL, Chou WH, Kwok CY. Elemene induces apoptosis and regulates expression of bcl-2 protein in human leukemia K562 cells. Zhongguo Yao Li Xue Bao. 1999 Feb;20(2):103-6. PMID 10437153
  9. Zhou HY, Shen JK , Hou JS , Qiu YM, Luo QZ. Experimental study on apoptosis induced by elemene in glioma cells. Aizheng = Chinese Journal of Cancer, 01 Sep 2003, 22(9):959-963. PMID 12969529
  10. Li CL, Chang L, Guo L, Zhao D, Liu HB, Wang QS, Zhang P, Du WZ, Liu X, Zhang HT, Liu Y, Zhang Y, Xie JH, Ming JG, Cui YQ, Sun Y, Zhang ZR, Jiang CL. β-elemene induces caspase-dependent apoptosis in human glioma cells in vitro through the upregulation of Bax and Fas/ FasL and downregulation of Bcl-2. Asian Pacific Journal of Cancer Prevention : APJCP [01 Jan 2014, 15(23):10407-10412] PMID 25556484
  11. Zhang H, Xu F, Xie T, Jin H, Shi L. β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein. Oncol Rep. 2012 Dec;28(6):2083-90. doi: 10.3892/or.2012.2022. PMID 22965456
  12. Xu YH, Dong B, Luo QZ, Zhou HY, Jia YC, Yang YF, Wang YZ. Influence of elemene on the expression of Bcl-2 family genes in rat C6 glioma cells. Zhonghua yi xue za zhi [01 Jun 2005, 85(24):1700-1703] PMID:16251076
  13. Yao YQ, Ding X, Jia YC, Huang CX, Wang YZ, Xu YH. Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation. Cancer Lett. 2008 Jun 8;264(1):127-34. doi: 10.1016/j.canlet.2008.01.049. PMID 18442668