Casticine

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Nom de la substance

Casticine, 3',5-dihydroxy-3,4',6,7-tétraméthoxyflavone

Famille moléculaire

Source végétale

Propriétés

  • Anti-inflammatoire in vitro et in vivo [1]
  • Antitumoral [2], [3], [4], induit l'apoptose de cellules leucémiques [5], de cellules d'hépatocarcinome in vitro [6], de cancer gastrique [7], de cancer du colon, en induisant l'apoptose liée au facteur de nécrose tumorale TNF (TRAIL) [8]
  • Anti-hyperprolactinémiant, neuroprotecteur, analgésique, immunomodulant [2]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Li YJ, Guo Y, Yang Q, Weng XG, Yang L, Wang YJ, Chen Y, Zhang D, Li Q, Liu XC, Kan XX, Chen X, Zhu XX, Kmoníèková E, Zídek Z. Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):151-8. doi: 10.1016/j.taap.2015.04.005. PMID 25891417
  2. 2,0 et 2,1 Rasul A, Zhao BJ, Liu J, Liu B, Sun JX, Li J, Li XM. Molecular mechanisms of casticin action: an update on its antitumor functions. Asian Pac J Cancer Prev. 2014;15(21):9049-58. PMID 25422178
  3. Chan EWC, Wong SK, Chan HT. Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties. J Integr Med. 2018 May;16(3):147-152. doi: 10.1016/j.joim.2018.03.001. PMID 29559215
  4. Haïdara K, Zamir L, Shi QW, Batist G. The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity action. Cancer Lett. 2006 Oct 28;242(2):180-90. PMID 16387422
  5. Shen JK, Du HP, Yang M, Wang YG, Jin J. Casticin induces leukemic cell death through apoptosis and mitotic catastrophe. Ann Hematol. 2009 Aug;88(8):743-52. doi: 10.1007/s00277-008-0677-3. PMID 19139893
  6. Yang J, Yang Y, Tian L, Sheng XF, Liu F, Cao JG. Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells. World J Gastroenterol. 2011 Oct 14;17(38):4298-307. doi: 10.3748/wjg.v17.i38.4298. PMID 22090786
  7. Zhou Y, Tian L, Long L, Quan M, Liu F, Cao J. Casticin potentiates TRAIL-induced apoptosis of gastric cancer cells through endoplasmic reticulum stress. PLoS One. 2013;8(3):e58855. doi: 10.1371/journal.pone.0058855. PMID 23536831
  8. Tang SY, Zhong MZ, Yuan GJ, Hou SP, Yin LL, Jiang H, Yu ZΥ. Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells. Oncol Rep. 2013 Feb;29(2):474-80. doi: 10.3892/or.2012.2127. PMID 23135489