Himachalol

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Nom de la substance

Himachalol, β-2-himachalen-6-ol, himachalen-ol

Famille moléculaire

Source végétale

Propriétés

Effet thérapeutique

  • Propriétés anticancéreuses prometteuses [1], [2]
  • Antifongique (Aspergillus fumigatus) [3]

Effets indésirables

Bibliographie

  1. Taleb RI, Najm P, Shebaby W, Boulos JC, Demirdjian S, Hariri E, El-Sibai M, Daher C, Mroueh M. β-2-himachalen-6-ol: A novel anticancer sesquiterpene unique to the Lebanese wild carrot. J Ethnopharmacol. 2016 Aug 22;190:59-67. doi: 10.1016/j.jep.2016.05.053. PMID 27240746
  2. Daaboul HE, Daher CF, Bodman-Smith K, Taleb RI, Shebaby WN, Boulos J, Dagher C, Mroueh MA, El-Sibai M. Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways. Chem Biol Interact. 2017 Sep 25;275:162-170. doi: 10.1016/j.cbi.2017.08.003. PMID 28782499
  3. Chowdhry L, Khan ZK, Kulshrestha DK. Comparative in vitro and in vivo evaluation of himachalol in murine invasive aspergillosis. Indian J Exp Biol. 1997 Jul;35(7):727-34. PMID 9418375