Naringine

De WikiPhyto

Nom de la substance

Naringine, Naringénine

Famille moléculaire

Flavonoïde (flavanone)

  • La naringénine est l'aglycone de la naringine après clivage de la fraction osidique par les bactéries intestinales

Source végétale

Propriétés

  • Anti-arythmique [1], interaction potentielle avec des médicaments anti-arythmiques [2]
  • Activité anti-inflammatoire et immuno-modulatrice, atténue l’inflammation des voies aériennes induite par un allergène [3]
  • Hypolipémiant par inhibition enzymatique (acyl-coenzyme A cholestérol acyltransférase et coenzyme-3-hydroxy-3-méthylglutaryl A-réductase), HMG-CoA réductase [4]
  • Neuroprotection dans la maladie de Parkinson [5], anti-oxydant
  • Anti-ulcéreux

Effet thérapeutique

Effets indésirables

  • Inhibition des enzymes du cytochrome P450 [6], surtout du cytochrome P450 3A4 (CYP3A4) [7], [8], [9]

Bibliographie

  1. Zitron E, Scholz E, Owen RW, Lück S, Kiesecker C, Thomas D, Kathöfer S, Niroomand F, Kiehn J, Kreye VA, Katus HA, Schoels W, Karle CA. QTc prolongation by grapefruit juice and its potential pharmacological basis: HERG channel blockade by flavonoids. Circulation. 2005 Feb 22;111(7):835-8. PMID 15710766
  2. Scholz EP, Zitron E, Kiesecker C, Lück S, Thomas D, Kathöfer S, Kreye VA, Katus HA, Kiehn J, Schoels W, Karle CA. Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):516-25. PMID 1600746
  3. Ying Shi, Jian Dai, Hua Liu, Ruo-Ran Li, Pei-Li Sun, Qiang Du, Ling-ling Pang, Zhen Chen, and Kai-Sheng Yin. Naringenin inhibits allergen-induced airway inflammation and airway responsiveness and inhibits NF-κB activity in a murine model of asthma. Can. J. Physiol. Pharmacol. 87(9): 729–735 (2009) [1]
  4. Lee Mi-Kyung, Moon Surk-Sik, Lee Seung-Eun, Bok Song-Hae, Jeong Tae-Sook, Yong Bok Park, Choi Myung-Sook. Naringenin 7-O-cetyl ether as inhibitor of HMG-CoA reductase and modulator of plasma and hepatic lipids in high cholesterol-fed rats. Bioorganic & medicinal chemistry. 2003, vol. 11, no3, pp. 393-398 [2]
  5. Zbarsky V, Datla KP, Parkar S, Rai DK, Aruoma OI, Dexter DT. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic Res. 2005 Oct;39(10):1119-25. PMID 16298737
  6. Fuhr U, Kummert AL. The fate of naringin in humans: a key to grapefruit juice-drug interactions? Clin Pharmacol Ther. 1995 Oct;58(4):365-73. PMID 7586927
  7. Ho PC, Saville DJ, Coville PF, Wanwimolruk S. Content of CYP3A4 inhibitors, naringin, naringenin and bergapten in grapefruit and grapefruit juice products. Pharm Acta Helv. 2000 Apr;74(4):379-85. PMID 10812937
  8. Arayne MS, Sultana N, Bibi Z. Grape fruit juice-drug interactions. Pak J Pharm Sci. 2005 Oct;18(4):45-57. PMID 16380358
  9. Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin Pharmacol Ther. 2003 Jun;73(6):529-37. PMID 12811362