Silymarine

De WikiPhyto

Nom de la substance

Silymarine

Famille moléculaire

Mélange de différents isomères du groupe des flavanolignanes

Source végétale

Propriétés

  • Hépatoprotecteur [1], [2], [3], [4]
  • Neuroprotecteur, augmente le niveau de glutathion et de superoxyde dismutase (SOD) dans le cerveau de rats. [5]
  • Photoprotecteur (brûlures cutanées) [6], et vis-à-vis de cancers de la peau [7]
  • Antivirale [8]

Effet thérapeutique

  • Prévention de la toxicité hépatique, hépatites
  • Maladies neuro-dégénératives

Effets indésirables

  • Modulation suspectée du cytochrome P 450

Bibliographie

  1. Das SK, Vasudevan DM. Protective effects of silymarin, a milk thistle (Silybium marianum) derivative on ethanol-induced oxidative stress in liver. Indian J Biochem Biophys. 2006 Oct;43(5):306-11. PMID 17133738
  2. Saller R, Brignoli R, Melzer J, Meier R. An updated systematic review with meta-analysis for the clinical evidence of silymarin. Forsch Komplementmed. 2008 Feb;15(1):9-20. doi: 10.1159/000113648. PMID 18334810
  3. Das SK, Mukherjee S. Biochemical and immunological basis of silymarin effect, a milk thistle (Silybum marianum) against ethanol-induced oxidative damage. Toxicol Mech Methods. 2012 Jun;22(5):409-13. doi: 10.3109/15376516.2012.673090. PMID 22409310
  4. Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010 Oct;24(10):1423-32. doi: 10.1002/ptr.3207. PMID 20564545
  5. Nencini C, Giorgi G, Micheli L. Protective effect of silymarin on oxidative stress in rat brain. Phytomedicine. 2007 Feb;14(2-3):129-35. PMID 16638633
  6. Toklu HZ, Tunali-Akbay T, Erkanli G, Yüksel M, Ercan F, Sener G. Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury. Burns. 2007 Nov;33(7):908-16. PMID 17521818
  7. Vaid M, Katiyar SK. Molecular mechanisms of inhibition of photocarcinogenesis by silymarin, a phytochemical from milk thistle (Silybum marianum L. Gaertn.) (Review). Int J Oncol. 2010 May;36(5):1053-60. PMID 20372777
  8. Liu J, Manheimer E, Tsutani K, Gluud C. Medicinal herbs for hepatitis C virus infection: a Cochrane hepatobiliary systematic review of randomized trials. Am J Gastroenterol. 2003 Mar;98(3):538-44. PMID 12650784