Taxifoline

De WikiPhyto

Nom de la substance

Taxifoline, dihydroquercétine

Famille moléculaire

Flavonoïde (flavanone)

Source végétale

Propriétés

  • Anti-oxydant
  • Anti-inflammatoire
  • Hypotenseur
  • Diminue la synthèse hépatique de lipides, diminue l’Apo-B, augmente l’Apo-A1, inhibe l’activité de l’HMG-CoA reductase (de 47 ± 7%) [2], [3]
  • Améliore la récupération de l'activité des enzymes mitochondriales dans les muscles squelettiques de la souris âgée [4]
  • Hépatoprotecteur par effet anti-oxydant [5]
  • Protection vis-à-vis de l'irradiation [6]
  • Chimio-prévention par activité sur les enzymes de phase 2 et la quinone reductase [7]
  • Neuroprotecteur [8], [9]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. P Lebreton, C Laracine-Pittet, C Bayet, J Lauranson. Variabilité polyphénolique et systématique du pin sylvestre Pinus sylvestris L. Ann. For. Sci. 47 (1990) 117-130
  2. Theriault, A., Q. Wang, S. C. Van Iderstine, B. Chen, A. A. Franke, and K. Adeli. Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid. J. Lipid Res. 2000. 41: 1969–1979
  3. Casaschi A, Rubio BK, Maiyoh GK, Theriault AG. Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion. Atherosclerosis. 2004 Oct;176(2):247-53. PMID 15380446
  4. G. E. Bronnikov, T. P. Kulagina, A. V. Aripovsky. Dietary supplementation of old mice with flavonoid dihydroquercetin causes recovery of the mitochondrial enzyme activities in skeletal muscles. Biochemistry (Mscow) supplemental series A: membrane and cell biology. Biomedical and life sciences. Volume 3, Number 4, 453-458
  5. Teselkin Yu O., Dihydroquercetin as a mean of antioxidative defence in rats with tetrachloromethane hepatitis, Phytotherapy Research, 2000 May, 14(3) : 495-502. PMID 10815007
  6. Teselkin Yu. O, Babenkova I. V, Tjukavkina N. A. Influence of dihydroquercetin on the lipid peroxidation of mice during post-radiation period. Phytotherapy research, 1998, vol. 12, n° 7, pp. 517-519 [1]
  7. Lee SB, Cha KH, Selenge D, Solongo A, Nho CW. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9. PMID 17541156
  8. Dok-Go H, Lee KH, Kim HJ, Lee EH, Lee J, Song YS, Lee YH, Jin C, Lee YS, Cho J. Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten. Brain Res. 2003 Mar 7;965(1-2):130-6. PMID 12591129
  9. Wang YH, Wang WY, Chang CC, Liou KT, Sung YJ, Liao JF, Chen CF, Chang S, Hou YC, Chou YC, Shen YC. Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation. J Biomed Sci. 2006 Jan;13(1):127-41. PMID 16283433
  • Patrick Trouillas, Philippe Marsal, Didier Siri, Roberto Lazzaroni, Jean-Luc Duroux. A DFT study of the reactivity of OH groups in quercetin and taxifolin antioxidants: The specificity of the 3-OH site. Food Chemistry, Volume 97, Issue 4, August 2006, Pages 679–688 [2]