Thuyanol

De WikiPhyto
(Redirigé depuis Trans-thuyanol-4)

Nom de la substance

Thuyanol, thujanol, 4-thujanol, thuyanol-4, thujanol-4

Famille moléculaire

Alcool monoterpénique

Source végétale

Propriétés

  • Contribue à un effet anti-infectieux [1], présenté comme immunostimulant, inducteur d'apoptose (?) [2]
  • Protège de la toxicité rénale et hépatique de l'acétate de plomb [3], et de la toxicité de certains médicaments anticancéreux [4]

Effet thérapeutique

Effets indésirables

  • Non cytotoxique ni génotoxique [5]

Bibliographie

  1. Schmidt E, Wanner J, Hiiferl M, Jirovetz L, Buchbauer G, Gochev V, Girova T, Stoyanova A, Geissler M. Chemical composition, olfactory analysis and antibacterial activity of Thymus vulgaris chemotypes geraniol, 4-thujanol/terpinen-4-ol, thymol and linalool cultivated in southern France. Nat Prod Commun. 2012 Aug;7(8):1095-8. PMID 22978238
  2. Krifa M, El Mekdad H, Bentouati N, Pizzi A, Ghedira K, Hammami M, El Meshri SE, Chekir-Ghedira L. Immunomodulatory and anticancer effects of Pituranthos tortuosus essential oil. Tumour Biol. 2015 Jul;36(7):5165-70. doi: 10.1007/s13277-015-3170-3. PMID 25663463
  3. Ibrahim M. El-Ashmawy, Abeer F. El-Nahas, Osama M. Salama. Protective Effect of Volatile Oil, Alcoholic and Aqueous Extracts of Origanum majorana on Lead Acetate Toxicity in Mice. Basic & Clinical Pharmacology & Toxicology, Volume 97, Issue 4, pages 238–243, October 2005. [1]
  4. Kocaman AY, Istifli ES, Büyükleyla M, Rencüzogullari E, Topaktaş M. In vitro evaluation of the protective effects of 4-thujanol against mitomycin-C and cyclophosphamide-induced genotoxic damage in human peripheral lymphocytes. Toxicol Ind Health. 2013 Feb;29(1):23-37. PMID 22323477
  5. Kocaman AY, Rencüzoğulları E, Topaktaş M, Istifli ES, Büyükleyla M. The effects of 4-thujanol on chromosome aberrations, sister chromatid exchanges and micronucleus in human peripheral blood lymphocytes. Cytotechnology. 2011 Oct;63(5):493-502. PMID 21735266
  • Bhatia SP, Letizia CS, Api AM. Fragrance material review on 4-thujanol. Food Chem Toxicol. 2008 Nov;46 Suppl 11:S295-6. PMID 18640194
  • Johannes Novak, Christina Bitsch, Jan Langbehn, Friedrich Pank, Melpo Skoula, Yiota Gotsiou, Chlodwig M. Franz. Ratios of cis- and trans-Sabinene Hydrate in Origanum majorana L. and Origanum microphyllum (Bentham) Vogel. Biochemical Systematics and Ecology, Volume 28, Issue 7, August 2000, Pages 697-704
  • Thompson JD, Chalchat JC, Michet A, Linhart YB, Ehlers B. Qualitative and quantitative variation in monoterpene co-occurrence and composition in the essential oil of Thymus vulgaris chemotypes. J Chem Ecol. 2003 Apr;29(4):859-80. PMID 12775148