Turmérone

De WikiPhyto

Nom de la substance

Turmérone

Famille moléculaire

Sesquiterpénoïde (cétone sesquiterpénique)

Source végétale

Propriétés

  • Inducteur d'apoptose sur cellules leucémiques (et non sur cellules de cancer gastrique)[1]
  • Antidépresseur [2]
  • Anti-inflammatoire [3]
  • Neuroprotecteur [4], [5], améliorerait la récupération de lésions cérébrales après AVC (diminue la neuro-inflammation, améliore la mobilisation des cellules souches endogènes) [6]

Effet thérapeutique

  • Anti-cancéreux (?)
  • Maladies neuro-dégénératives (?)

Effets indésirables

Bibliographie

  1. Aratanechemuge Y, Komiya T, Moteki H, Katsuzaki H, Imai K, Hibasami H. Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line. Int J Mol Med. 2002 May;9(5):481-4. PMID 11956652
  2. Liao J, Tsai J, Liu C, Huang H, Wu L, Peng W. Antidepressant-like activity of turmerone in behavioral despair tests in mice. BMC Complementary and Alternative Medicine 2013, 13:299 (1 November 2013) Abstract texte intégral
  3. Oh S, Han AR, Park HR, Jang EJ, Kim HK, Jeong MG, Song H, Park GH, Seo EK, Hwang ES. Suppression of Inflammatory cytokine production by ar-Turmerone isolated from Curcuma phaeocaulis. Chem Biodivers. 2014 Jul;11(7):1034-41. doi: 10.1002/cbdv.201300397. PMID 25044589
  4. Park SY, Jin ML, Kim YH, Kim Y, Lee SJ. Anti-inflammatory effects of aromatic-turmerone through blocking of NF-κB, JNK, and p38 MAPK signaling pathways in amyloid β-stimulated microglia. Int Immunopharmacol. 2012 Sep;14(1):13-20. doi: 10.1016/j.intimp.2012.06.003. PMID 22728094
  5. Park SY, Kim YH, Kim Y, Lee SJ. Aromatic-turmerone's anti-inflammatory effects in microglial cells are mediated by protein kinase A and heme oxygenase-1 signaling. Neurochem Int. 2012 Oct;61(5):767-77. doi: 10.1016/j.neuint.2012.06.020. PMID 22766494
  6. Poser SW, Androutsellis-Theotokis A. Spicing up endogenous neural stem cells: aromatic-turmerone offers new possibilities for tackling neurodegeneration. Stem Cell Res Ther. 2014 Nov 17;5(6):127. doi: 10.1186/scrt517. PMID 25688994
  • Chae Hee Hong, Min Soo Noh, Woo Young Lee, Sang Kook Lee. Inhibitory Effects of Natural Sesquiterpenoids Isolated from the Rhizomes of Curcuma zedoaria on Prostaglandin E2 and Nitric Oxide Production. Planta Med 2002; 68: 545-547 [1]