Wogonine
(Redirigé depuis Wogonoside)
Nom de la substance
Wogonine, wogonoside, 5,7-dihydroxy-8-méthoxyflavone
Famille moléculaire
Source végétale
Propriétés
- Antioxydant [1]
- Antiviral
- Anticoagulant, fibrinolytique [2]
- Anti-inflammatoire par inhibition sélective de la COX-2 [3]
- Anxiolytique [4]
- Anti-allergique par régulation du déséquilibre Th1 / Th2 et de la libération d'histamine [5]
- Induction de l’apoptose dans les cellules leucémiques humaines HL-60 [6] et dans les cellules d'hépato-carcinome SK-HEP-1 [7], intérêt dans les cancers du sein agressifs et résistants aux thérapeutiques [8]
Effet thérapeutique
- Prévention des cancers
- Anxiété, pathologies neuropsychiatriques
Effets indésirables
Bibliographie
- ↑ Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochim Biophys Acta. 1999 Nov 16;1472(3):643-50. PMID 10564778
- ↑ Kimura Y, Okuda H, Ogita Z. Effects of flavonoids isolated from scutellariae radix on fibrinolytic system induced by trypsin in human umbilical vein endothelial cells. J Nat Prod. 1997 Jun;60(6):598-601. PMID 9214730
- ↑ Chi YS, Lim H, Park H, Kim HP. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem Pharmacol. 2003 Oct 1;66(7):1271-8. PMID 14505806
- ↑ Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, Baur R, Ren H, Li ZW, Wong JT, Xue H. Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Biochem Pharmacol. 2002 Nov 1;64(9):1415-24. doi: 10.1016/s0006-2952(02)01347-3. PMID 12392823.
- ↑ Bui TT, Piao CH, Song CH, Lee CH, Shin HS,5, Chai OH. Baicalein, wogonin, and Scutellaria baicalensis ethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release. Anat Cell Biol. 2017 Jun;50(2):124-134. doi: 10.5115/acb.2017.50.2.124. PMID 28713616
- ↑ Lee WR, Shen SC, Lin HY, Hou WC, Yang LL, Chen YC. Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. Biochem Pharmacol. 2002 Jan 15;63(2):225-36. PMID 11841797
- ↑ Chen YC, Shen SC, Lee WR, Lin HY, Ko CH, Shih CM, Yang LL. Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. Arch Toxicol. 2002 Jun;76(5-6):351-9. PMID 12107653
- ↑ Chung H, Jung YM, Shin DH, Lee JY, Oh MY, Kim HJ, Jang KS, Jeon SJ, Son KH, Kong G. Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. Int J Cancer. 2008 Feb 15;122(4):816-22. PMID 17957784