Alpha-amyrine

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Nom de la substance

Alpha-amyrine et béta-amyrine

Famille moléculaire

Triterpénoïde, triterpène pentacyclique (alcool triterpénique)

Source végétale

Propriétés

  • Nombreuses propriétés répertoriées dans une revue de littérature : analgésique, anti-inflammatoire, anticonvulsivant, antidépresseur, gastroprotecteur, hépatoprotecteur, antipancréatite, anticholytique, antihyperglycémiant, hypolipidémiant [2]
  • Hépatoprotecteur [3]
  • Gastroprotecteur [4]
  • Antalgique [5], [6], probablement par inhibition des voies impliquant les protéines kinases A et C [7], inhibe la douleur viscérale induite par la capsaïcine [8]
  • Anti-inflammatoire [9], [10], dans les colites [11], [12] et dans les pancréatites aiguës [13], [14]
  • Protection de la peau
  • Propriétés antifongiques et antibactériennes

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Liliana Hernández Vázquez, Javier Palazon, Arturo Navarro-Ocaña. The Pentacyclic Triterpenes alpha, béta-amyrins: A Review of Sources and Biological Activities texte intégral
  2. Nogueira AO, Oliveira YIS, Adjafre BL, de Moraes MEA, Aragão GF. Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review. Fundam Clin Pharmacol. 2019 Feb;33(1):4-12. doi: 10.1111/fcp.12402. PMID 30003594
  3. Oliveira FA, Chaves MH, Almeida FR, Lima RC Jr, Silva RM, Maia JL, Brito GA, Santos FA, Rao VS. Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice. J Ethnopharmacol. 2005 Apr 8;98(1-2):103-8. PMID 15763370
  4. Oliveira FA, Vieira-Júnior GM, Chaves MH, Almeida FR, Santos KA, Martins FS, Silva RM, Santos FA, Rao VS. Gastroprotective effect of the mixture of alpha- and beta-amyrin from Protium heptaphyllum: role of capsaicin-sensitive primary afferent neurons. Planta Med. 2004 Aug;70(8):780-2. PMID 15368675
  5. Lima-Junior RC, Oliveira FA, Gurgel LA, Cavalcante IJ, Santos KA, Campos DA, Vale CA, Silva RM, Chaves MH, Rao VS, Santos FA. Attenuation of visceral nociception by alpha- and beta-amyrin, a triterpenoid mixture isolated from the resin of Protium heptaphyllum, in mice. Planta-Med. 2006 Jan; 72(1): 34 PMID 16450293
  6. Aragão GF, Cunha Pinheiro MC, Nogueira Bandeira P, Gomes Lemos TL, de Barros Viana GS. Analgesic and anti-inflammatory activities of the isomeric mixture of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) march. J Herb Pharmacother. 2007;7(2):31-47. PMID 18285306
  7. Otuki MF, Ferreira J, Lima FV, Meyre-Silva C, Malheiros A, Muller LA, Cani GS, Santos AR, Yunes RA, Calixto JB. Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways. J Pharmacol Exp Ther. 2005 Apr;313(1):310-8. PMID 15626726
  8. Oliveira FA, Costa CL, Chaves MH, Almeida FR, Cavalcante IJ, Lima AF, Lima RC Jr, Silva RM, Campos AR, Santos FA, Rao VS. Attenuation of capsaicin-induced acute and visceral nociceptive pain by alpha- and beta-amyrin, a triterpene mixture isolated from Protium heptaphyllum resin in mice. Life Sci. 2005 Oct 21;77(23):2942-52. PMID 15964027
  9. de Oliveira LS, Tschoeke DA, de Oliveira AS, Hill LJ, Paradas WC, Salgado LT, Thompson CC, Pereira RC, Thompson FL. New Insights on the terpenome of the red seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta). Mar Drugs. 2015 Feb 10;13(2):879-902. doi: 10.3390/md13020879. PMID 25675000
  10. Carretero ME, López-Pérez JL, Abad MJ, Bermejo P, Tillet S, Israel A, Noguera-P B. Preliminary study of the anti-inflammatory activity of hexane extract and fractions from Bursera simaruba (Linneo) Sarg. (Burseraceae) leaves. J Ethnopharmacol. 2008 Feb 28;116(1):11-5. PMID 18155865
  11. Vitor CE, Figueiredo CP, Hara DB, Bento AF, Mazzuco TL, Calixto JB. Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, alpha- and beta-amyrin, in a mouse model of colitis. Br J Pharmacol. 2009 Jul;157(6):1034-44. doi: 10.1111/j.1476-5381.2009.00271.x. PMID 19508397
  12. Matos I, Bento AF, Marcon R, Claudino RF, Calixto JB. Preventive and therapeutic oral administration of the pentacyclic triterpene α,β-amyrin ameliorates dextran sulfate sodium-induced colitis in mice: the relevance of cannabinoid system. Mol Immunol. 2013 Jul;54(3-4):482-92. doi: 10.1016/j.molimm.2013.01.018. PMID 23454360
  13. Melo CM, Carvalho KM, Neves JC, Morais TC, Rao VS, Santos FA, Brito GA, Chaves MH. alpha,beta-amyrin, a natural triterpenoid ameliorates L-arginine-induced acute pancreatitis in rats. World J Gastroenterol. 2010 Sep 14;16(34):4272-80. PMID 20818810
  14. Melo CM, Morais TC, Tomé AR, Brito GA, Chaves MH, Rao VS, Santos FA. Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice. Inflamm Res. 2011 Jul;60(7):673-81. doi: 10.1007/s00011-011-0321-x. PMID 21400110