Orthosiphon

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Orthosiphon stamineus

Nom de la plante

Orthosiphon, Moustache de chat, Thé de Java

Dénomination latine internationale

Orthosiphon stamineus Benth. = Orthosiphon aristatus (Blume) Miq. ou Orthosiphon spicatus (Thunb.) Bak.

Famille botanique

Lamiaceae

Description et habitat

  • Plante pérenne originaire du sud-est asiatique, importée d'Indonésie, cultivée sous climat chaud et humide
  • Tige quadrangulaire, feuilles opposées, irrégulièrement dentées, longuement pétiolées
  • Fleurs, blanches ou lilas, disposées en verticilles au sommet de la tige, avec étamines exsertes deux fois plus longues que le tube de la corolle (d'où son nom vernaculaire de " moustache de chat ", kumis-kuting)

Histoire et tradition

Parties utilisées

  • Feuilles

Formes galéniques disponibles

Dosages usuels

Composition

Composants principaux de la plante

Composants principaux des bourgeons ou jeunes pousses

Composants principaux de l'huile essentielle

Propriétés

Propriétés de la plante

Propriétés du bourgeon

Propriétés de l'huile essentielle

Indications

Indications de la plante entière (phytothérapie)

  • Facilite les fonctions d'élimination rénales et digestives, facilite l'élimination rénale d'eau et adjuvant des traitements amaigrissants [19]
  • Inflammations rénales et vésicales chroniques, bactériuries asymptomatiques
  • Lithiases rénales [20]
  • Drainage

Indications du bourgeon (gemmothérapie)

Indications spécifiques de l'huile essentielle (aromathérapie)

Mode d'action connu ou présumé

  • Propriétés antihormonales de l’acide lithospermique
  • Les lithospermates ont des effets favorables sur le fonctionnement rénal, diminution de l’urémie, augmentation de la vitesse de filtration glomérulaire, de l’excrétion d’urée et de créatinine, inhibe l’hépatotoxicité du tétrachlorure de Carbone

Formulations usuelles

Réglementation

Effets indésirables éventuels et précautions d'emploi

  • Aucun connu [21], [22], pas de génotoxicité [23]
  • Interactions médicamenteuses possibles :

Références bibliographiques

  1. Yoshio Takeda, Takashi Matsumoto, Hiromitsu Terao, Tetsuro Shingu, Yukako Futatsuishi, Toshihiro Nohara, Tetsuya Kajimoto. Orthosiphol D and E, minor diterpenes from Orthosiphon stamineus. Phytochemistry, Volume 33, Issue 2, 13 May 1993, Pages 411-415 [1]
  2. Adam Y, Somchit MN, Sulaiman MR, Nasaruddin AA, Zuraini A, Bustamam AA, Zakaria ZA. Diuretic properties of Orthosiphon stamineus Benth. J Ethnopharmacol. 2009 Jul 6;124(1):154-8. doi: 10.1016/j.jep.2009.04.014. PMID 19375494
  3. Schut G.A. Zwaving J.H. Pharmacological investigation of some lipophilic flavonoids from Orthosiphon aristatus Fitoterapia 1993 64(2): 99-102
  4. Englert J, Harnischfeger G. Diuretic action of aqueous Orthosiphon extract in rats. Planta Med. 1992 Jun;58(3):237-8. PMID 1409978
  5. Olah NK, Radu L, Mogoşan C, Hanganu D, Gocan S. Phytochemical and pharmacological studies on Orthosiphon stamineus Benth. (Lamiaceae) hydroalcoholic extracts. J Pharm Biomed Anal. 2003 Sep 15;33(1):117-23. PMID 12946538
  6. Alia Azizan, Nurul & Ahmad, Rashidi & Koriem, Khaled & Ahmad, Mohammad Zikri & Asmawi, Mohd. The in vivo antihypertensive effects of standardized methanol extracts of Orthosiphon stamineus on spontaneous hypertensive rats: A preliminary study. African Journal of Pharmacy and Pharmacology Vol.6(6), pp. 376 - 379, February 2012 https://doi.org/10.5897/AJPP11.362
  7. Yam MF, Tan CS, Shibao R. Vasorelaxant effect of sinensetin via the NO/sGC/cGMP pathway and potassium and calcium channels. Hypertens Res. 2018 Oct;41(10):787-797. doi: 10.1038/s41440-018-0083-8. PMID 30111856
  8. Tan CS, Yam MF. Mechanism of vasorelaxation induced by 3'-hydroxy-5,6,7,4'-tetramethoxyflavone in the rats aortic ring assay. Naunyn Schmiedebergs Arch Pharmacol. 2018 Jun;391(6):561-569. doi: 10.1007/s00210-018-1481-9. PMID 29552696
  9. Arafat OM, Tham SY, Sadikun A, Zhari I, Haughton PJ, Asmawi MZ. Studies on diuretic and hypouricemic effects of Orthosiphon stamineus methanol extracts in rats. J Ethnopharmacol. 2008 Aug 13;118(3):354-60. doi: 10.1016/j.jep.2008.04.015. PMID 18602231
  10. G.A. Akowuah, I. Zhari, A. Sadikun & I. Norhayati. HPTLC Densitometric Analysis of Orthosiphon stamineus. Leaf Extracts and Inhibitory Effect on Xanthine Oxidase Activity. Pharmaceutical Biology Vol. 44 , Iss. 1,2006
  11. Yam MF, Asmawi MZ, Basir R. An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extract. J Med Food. 2008 Jun;11(2):362-8. doi: 10.1089/jmf.2006.065. PMID 18598181
  12. Toshiya Masuda, Kazuyo Masuda, Shizuno Shiragami, Akiko Jitoe, Nobuji Nakatani. Orthosiphol A and B, novel diterpenoid inhibitors of TPA (12-O-tetradecanoylphorbol-13-acetate)-induced inflammation, from Orthosiphon stamineus. Tetrahedron, Volume 48, Issue 33, 1992, Pages 6787-6792 [2]
  13. Mun Fei Yam, Vuanghao Lim, Ibrahim Muhammad Salman, Omar Ziad Ameer, Lee Fung Ang, Noersal Rosidah, Muthanna Fawzy Abdulkarim, Ghassan Zuhair Abdullah, Rusliza Basir, Amirin Sadikun, Mohd Zaini Asmawi. HPLC and Anti-Inflammatory Studies of the Flavonoid Rich Chloroform Extract Fraction of Orthosiphon Stamineus Leaves. Molecules 2010, 15, 4452-4466
  14. Mariam A, Asmawi MZ, Sadikun A. Hypoglycaemic activity of the aqueous extract of Orthosiphon stamineus. Fitoterapia, 1996, vol. 67, no5, pp. 465-468 [3]
  15. Mohamed EA, Yam M, Siddiqol MJ, Asmawi MZ, Sadikun A, Ang L, Tan S, Chan S. Potent alpha-glucosidase and alpha-amylase inhibitory activities of standardized 50% ethanolic extracts and sinensetin from Orthosiphon stamineus Benth as anti-diabetic mechanism. BMC Complementary and Alternative Medicine 2012, 12:176 (8 October 2012) Abstract Provisional PDF
  16. Sriplang K, Adisakwattana S, Rungsipipat A, Yibchok-Anun S. Effects of Orthosiphon stamineus aqueous extract on plasma glucose concentration and lipid profile in normal and streptozotocin-induced diabetic rats. J Ethnopharmacol. 2007 Feb 12;109(3):510-4. PMID 17034971
  17. Mun Fei Yam. Antioxidant and Hepatoprotective Effects of Orthosiphon stamineus Benth. Standardized Extract. The American Journal of Chinese Medicine (AJCM), Volume: 35, Issue: 1(2007) pp. 115-126 [4]
  18. G.A Akowuah, I Zhari, I Norhayati, A Sadikun, S.M Khamsah. Sinensetin, eupatorin, 3′-hydroxy-5, 6, 7, 4′-tetramethoxyflavone and rosmarinic acid contents and antioxidative effect of Orthosiphon stamineus from Malaysia. Food Chemistry, Volume 87, Issue 4, October 2004, Pages 559-566 [5]
  19. Ameer OZ, Salman IM, Asmawi MZ, Ibraheem ZO, Yam MF. Orthosiphon stamineus: traditional uses, phytochemistry, pharmacology, and toxicology. J Med Food. 2012 Aug;15(8):678-90. doi: 10.1089/jmf.2011.1973. PMID 22846075
  20. Yuliana ND, Khatib A, Link-Struensee AM, Ijzerman AP, Rungkat-Zakaria F, Choi YH, Verpoorte R. Adenosine A1 receptor binding activity of methoxy flavonoids from Orthosiphon stamineus. Planta Med. 2009 Feb;75(2):132-6. doi: 10.1055/s-0028-1088379. PMID 19137497
  21. Chin JH, Abas HH, Sabariah I. Toxicity study of Orthosiphon stamineus Benth (Misai Kucing) on Sprague Dawley rats. Trop Biomed. 2008 Apr;25(1):9-16. PMID 18600199 texte intégral
  22. Mohamed EA, Lim CP, Ebrika OS, Asmawi MZ, Sadikun A, Yam MF. Toxicity evaluation of a standardised 50% ethanol extract of Orthosiphon stamineus. J Ethnopharmacol. 2011 Jan 27;133(2):358-63. doi: 10.1016/j.jep.2010.10.008. PMID 20937371
  23. Muhammad H, Gomes-Carneiro MR, Poça KS, De-Oliveira AC, Afzan A, Sulaiman SA, Ismail Z, Paumgartten FJ. Evaluation of the genotoxicity of Orthosiphon stamineus aqueous extract. J Ethnopharmacol. 2011 Jan 27;133(2):647-53. doi: 10.1016/j.jep.2010.10.055. PMID 21044879
  24. Ismail S, Hanapi NA, Ab Halim MR, Uchaipichat V, Mackenzie PI. Effects of Andrographis paniculata and Orthosiphon stamineus extracts on the glucuronidation of 4-methylumbelliferone in human UGT isoforms. Molecules. 2010 May 14;15(5):3578-92. doi: 10.3390/molecules15053578. PMID 20657500
  25. Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC, Er HM, Ong CE. In vitro effects of active constituents and extracts of Orthosiphon stamineus on the activities of three major human cDNA-expressed cytochrome P450 enzymes. Chem Biol Interact. 2011 Mar 15;190(1):1-8. doi: 10.1016/j.cbi.2011.01.022. PMID 21276781
  • Bruneton J. Pharmacognosie, Phytochimie, Plantes médicinales. Ed. Tec et Doc. 1997. p. 220
  • M. Amzad Hossain, S.M. Mizanur Rahman. Isolation and characterisation of flavonoids from the leaves of medicinal plant Orthosiphon stamineus. Arabian Journal of Chemistry, 2011 [6]